Principal Investigator
From Seattle, WA
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Updated 03/01/2013

Matt Kaeberlein

Dr. Kaeberlein graduated with a B.S. in Biochemistry and a B.A. in Mathematics from Western Washington University in 1997. He earned his Ph.D. from the Massachusetts Institute of Technology in 2002, and performed his post-doctoral studies in the laboratory of Dr. Stanley Fields in the Department of Genome Sciences at the University of Washington. Dr. Kaeberlein was appointed to his current position as an Assistant Professor in the Department of Pathology at the University of Washington in 2006 and is the incoming Associate Director of the University of Washington Nathan Shock Center of Excellence in the Basic Biology of Aging.

Research in the Kaeberlein Lab is centered on understanding the genetic and environmental factors that control aging using yeast, nematodes, and mice as model systems.  His group has contributed to seminal discoveries in this area, including defining the importance of sirtuins in aging, the role of TOR signaling in the response to dietary restriction, and the identification of the hypoxic response as a new longevity pathway.  Dr. Kaeberlein has coauthored more than 70 publications in top scientific journals and books, and he has been recognized with several prestigious awards including selection as an Alzheimer’s Association New Investigator, an Ellison Medical Foundation New Scholar in Aging Award, and a Breakthroughs in Gerontology Award from the Glenn Foundation and the American Federation for Aging Research.  In 2009, Dr. Kaeberlein was appointed as a Distinguished Visiting Professor at Guangdong Medical College in Dongguan, China.

Research Interests

Degrees

Awards

Publications

Defossez, P. A., Prusty, R., Kaeberlein, M., Lin, S. J., Ferrigno, P., Silver, P. A., Keil, R. L., and Guarente, L. (1999). Elimination of replication block protein Fob1 extends the life span of yeast mother cells. Mol Cell 3, 447-55.

Kaeberlein, M., McVey, M., and Guarente, L. (1999). The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13, 2570-80.

Pultz, M. A., Zimmerman, K. K., Alto, N. M., Kaeberlein, M., Lange, S. K., Pitt, J. N., Reeves, N. L., and Zehrung, D. L. (2000). A genetic screen for zygotic embryonic lethal mutations affecting cuticular morphology in the wasp Nasonia vitripennis. Genetics 154, 1213-29.

Imai, S., Armstrong, C. M., Kaeberlein, M., and Guarente, L. (2000). Transcriptional silencing and longevity protein Sir2 is an NAD- dependent histone deacetylase. Nature 403, 795-800.

McVey, M., Kaeberlein, M., Tissenbaum, H. A., and Guarente, L. (2001). The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination. Genetics 157, 1531-42.

Kaeberlein, M., McVey, M., and Guarente, L. (2001).  Using yeast to discover the fountain of youth.  Sci Aging Knowl Environ 2001, pe1

Kaeberlein, M.,  Andalis, A. A., Fink, G. R., and Guarente, L. (2002) High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism resembling calorie restriction.  Mol Cell Biol 22, 8056-66.

Kaeberlein, M., Jegalian, B., and McVey, M. (2002). AGEID: a database of aging genes and interventions. Mech Ageing Dev 123, 1115-9.

Lin, S. J., Kaeberlein, M., Andalis, A. A., Sturtz, L. A., P., D., Culotta, V. C., Fink, G., and Guarente, L. (2002). Calorie restriction extends Saccharomyces cerevisiae life span by increasing respiration. Nature 418, 344-48.

Armstrong, C. M., Kaeberlein, M., Imai, S. I., and Guarente, L. (2002). Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity. Mol Biol Cell 13, 1427-38.

Kaeberlein, M., and Guarente, L. (2002). Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics 160, 83-95.

Kaeberlein, M. and Russo, S. F.  (2002) A comparison of the thermostability of glyceraldehyde 3-phosphate dehydrogenase from thermophiles and mesophiles in different ionic salt solutions.  Journal of Young Investigators 6.

Kaeberlein, M.  Aging research in the ‘omics age’ (2004).  Sci Aging Knowl Environ 2004, pe39

Kaeberlein, M., Andalis, A. A., Liszt, G., Fink, G. R., and Guarente, L. (2004) Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism. Genetics 166, 1661-72.

Kaeberlein, M., Kirkland, K. T., Fields, S., and Kennedy, B. K. (2004). Sir2-indepdendent life span extension by calorie restriction in yeast. PLoS Biol 2, E296.

Hudson, F. N., Kaeberlein, M., Linford, N., Pritchard, D., Beyer, R., and Rabinovitch, P. S. (2005).  Microarray analysis of gene expression changes in aging.  Handbook of the Biology of Aging, 6th Edition.  E.J. Masoro and S. N. Austad (Eds.)

Kaeberlein, M., McDonagh, T., Heltweg, B., Hixon, J., Westman, E. A., Caldwell, S. D., Napper, A., Curtis, R., Distefano, P. S., Fields, S., et al. (2005). Substrate-specific activation of sirtuins by resveratrol. J Biol Chem 280, 17038-17045.

Kaeberlein, M., Kirkland, K. T., Fields, S., and Kennedy, B. K. (2005). Genes determining yeast replicative life span in a long-lived genetic background. Mech Ageing Dev 126, 491-504.

Kaeberlein, M., and Kennedy, B. K. (2005). Large-scale identification in yeast of conserved ageing genes. Mech Ageing Dev 126, 17-21.

Kaeberlein, M., Steffen, K. K., Hu D., Dang N., Kerr E.O., Tsuchiya, M., Westman, E. A., Fields, S., Kennedy, B.K. (2005) Calorie restriction increases life span in respiratory deficient yeast. PLoS Genet 1, E69

Kaeberlein, M., Powers, R. W., Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., and Kennedy, B. K. (2005). Regulation of yeast replicative life span by Tor and Sch9 in response to nutrients. Science 310, 1193-1196.

Kennedy, B. K., Smith, E. D., Kaeberlein, M. (2005) The enigmatic role of sir2 in aging.  Cell 124, 548-550.

Kaeberlein, M., (2006).  Longevity and aging in the budding yeast.  Handbook of Models for Human Aging, M. Conn (Ed.)

Kaeberlein, M., (2006).  Application of high-throughput technologies to aging-related research.  Handbook of Models for Human Aging, M. Conn (Ed.)

Kaeberlein M., Hu, D., Kerr, E. O., Tsuchiya, M., Westman, E. A., Dang, N., Fields, S., Kennedy, B. K. (2006). Author's Reply. PLoS Genet 2, e34.

Powers, R. W., Kaeberlein, M., Caldwell, S. D., Kennedy, B. K., Fields, S. (2006). Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev 20, 174-184.

Kaeberlein, M., Steffen K.K., Hu D., Dang N., Kerr E.O., Tsuchiya, M., Fields, S., Kennedy, B. K. (2006). Comment on: HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction. Science 312,1312.

Kaeberlein, M.  (2006). Genome-wide approaches to understanding human aging. Hum Genom 2, 422-428.

Kaeberlein, T, Smith, E. D., Tsuchiya, M., Welton, K. L., Thomas, J. H., Kennedy, B. K., Kaeberlein, M. (2006). Life span extension in Caenorhabditis elegans by complete removal of food.  Aging Cell 5, 487-494.

Tsuchiya, M., Dang, N., Kerr, E. O., Hu, D., Steffen, K. K., Oakes, J. A., Kennedy, B. K., Kaeberlein, M. (2006). Sirtuin-independent effects of nicotinamide on life span extension from calorie restriction.  Aging Cell. 5, 505-514.

Kaeberlein, M., Rabinovitch, P. S. (2006). Grapes versus gluttony. Nature  444, 280-281.

Smith, E. D., Kennedy, B. K., Kaeberlein, M. (2007). Genome-wide identification of conserved longevity genes in yeast and worms. Mech Ageing Dev.  128, 106-111.

Lockshon, D., Surface, L.E., Kerr, E. O., Kaeberlein, M., Kennedy, B. K. (2007). The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function. Genetics. 175, 77-91.

Kaeberlein, M., Burtner, C. R., Kennedy, B. K. (2007). Recent developments in yeast aging. PLoS Genet.  3, e84.

Kennedy, B. K., Steffan, K., Kaeberlein, M. Ruminations on calorie restriction and aging. (2007). Cell Mol Life Sci. 64, 1323-1328.

Powers, R. W., Kaeberlein, M. (2007). Sir2 and calorie restriction: A skeptic’s perspective. Age Res. Rev. 6, 128-140.

Kaeberlein, M. (2007). Longevity genomics across species.  Curr Genom. 8, 73-78.

Kaeberlein, M, Kennedy B. K. (2007). Does resveratrol activate yeast Sir2 in vivo? Aging Cell. 6, 731-734.

Kaeberlein, M. (2007). Molecular basis of aging.  EMBO Reports. 8, 907-911.

Kaeberlein, M., Kennedy, B. K.  (2007). Protein translation, 2007. Aging Cell 6, 731-734.

Schmidlin, T., Kaeberlein, M., Kudlow, B. A., MacKay, V., Lockshon, D., Kennedy, B. K. (2008) Single-gene deletions that restore mating competence to diploid yeast. FEMS Yeast Res. 8, 276-86.

Sutphin, G. L. and Kaeberlein, M. (2008). Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes. Exp. Gerontol. 43,130-135.

Murakami, C. J., Burtner, C. R., Kennedy, B. K., Kaeberlein, M. (2008).  A method for high-throughput quantitative analysis of yeast chronological life span. J. Gerontol. Biol. Sci. A. 63, 113-121.

Smith, E. D., Tsuchiya, M., Fox, L. A., Dang, N., Hu, D., Kerr, E. O., Johnston, E. D., Tchao, B. N., Pak, D. N., Welton, K. L., Promislow, D. E. L., Thomas, J. H., Kaeberlein, M., Kennedy, B. K. (2008). Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome Res. 18, 564-570.

Steinkraus, K. A., Smith, E. D., Davis, C., Carr, D., Pendergrass, W. R., Sutphin, G. L., Kennedy, B. K., Kaeberlein, M. (2008). Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in C. elegans.  Aging Cell. Feb 20. Early online.

Steffen, K. K., MacKay, V. L., Kerr, E. O., Tsuchiya, M., Hu, D., Fox, L. A., Dang, N., Johnston, E. D., Oakes, J. A., Tchao, B. N., Pak, D. N., Fields, S., Kennedy, B. K., Kaeberlein, M. (2008).  Yeast lifespan extension by depletion of 60S ribosomal subunits is mediated by Gcn4.  Cell. 133, 292-302.

Effros, R. B., Austad, S., Blau, H., Chesselet, M., Ingram, D., Johnson, T. E., Kaeberlein, M., Lundblad, V., McCarter, R., McElhaney, J., Saag, M. (2008). The biological sciences section program at the 60th annual meeting of the Gerontological Society of America.  J. Gerontol. Biol. Sci. A. 63, 331-337.

Smith E. D., Kaeberlein, T. L., Lydum, B. T., Sager, J., Welton, K. L., Kennedy, B. K., Kaeberlein, M. (2008). Age- and calorie-independent life span extension from bacterial food deprivation in Caenorhabditis elegans.  BMC Dev. Biol. 8, 59.

Steinkraus, K. A., Kaeberlein, M., Kennedy, B. K. (2008). Replicative aging in yeast: the means to the end. Ann. Rev. Cell. Dev. Biol. 24, 29-54.

Kaeberlein, M. (2008). The ongoing saga of sirtuins and aging.  Cell Metab. 8, 4-5.

Kaeberlein, M., Kennedy, B. K. (2008). Hot topics protein translation, 2008. Aging Cell 7, 777-782.

Kaeberlein, M. (2008). A molecular age barrier.  Nature 454, 709-710.

Managbanag, J. R., Witten, T. M., Bonchev, D., Fox, T. A., Tsuchiya, M., Kennedy, B. K., Kaeberlein, M. (2008). Shortest-path network analysis Is a useful approach toward identifying genetic determinants of longevity.  PLoS One 3, e3802

Burtner, C. R., Murakami, C. J., Kaeberlein, M. (2009). A genomic approach to yeast aging.  Methods Mol Biol 548, 101-114.

Burtner, C. R., Murakami, C. J., Kennedy, B., K., Kaeberlein, M. (2009). A molecular mechanism of chronological aging in yeast. Cell Cycle 8, 1256-1270.

Murakami, C., Kaeberlein, M. (2009) Quantifying yeast chronological life span by outgrowth of aged cells. J Vis Exp. May 6;(27). pii: 1156. doi: 10.3791/1156.

Sutphin, G. L., Kaeberlein, M. (2009) Measuring Caenorhabditis elegans Life Span on Solid Media.  J Vis Exp. May 12;(27). pii: 1152. doi: 10.3791/1152.

Steffen, K. K., Kennedy, B. K., Kaeberlein, M. (2009). Measuring Replicative Life Span in the Budding Yeast.  J Vis Exp. Jun 25;(28). pii: 1209. doi: 10.3791/1209.

Mehta, R., Steinkraus, K. A., Sutphin, G., Ramos, F. J., Shamieh, L., S., Huh, A., Davis, C., Chandler-Brown, D., Kaeberlein, M. (2009). Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science 324: 1196-1198.

Dang, W., Steffen, K. K., Perry, R., Dorsey, J., Johnson, F. B., Shilatifard, A., Kaeberlein, M., Kennedy, B. K., Berger, S. (2009). LHistone H4 lysine-16 acetylation regulates cellular lifespan. Nature 459, 802-807.

Stanfel, M. N., Shamieh, L. S., Kaeberlein, M., Kennedy, B. K. (2009). The TOR pathway comes of age.  Biochim Biophys Acta. 1790, 1067-1074.

Kaeberlein, M., Kennedy, B. K. (2009) A midlife longevity drug? Nature 460, 331-332.

Kaeberlein, M., Kapahi, P. (2009). The hypoxic response and aging.  Cell Cycle 8, 2324.

Kennedy, B. K., Kaeberlein, M. (2009). Hot topics in aging research: protein translation. Aging Cell 8, 617-623.

Enns, L. C., Morton, J. F., Mangalindan, R. S., McKnight, S., Schwartz, M. W., Kaeberlein, M., Kennedy, B. K., Rabinovitch, P. S., Ladiges, W. (2009) Attenuation of Age-Related Metabolic Dysfunction in Mice With a Targeted Disruption of the C{beta} Subunit of Protein Kinase A..  J. Gerontol. 64, 1221-1231.

Kaeberlein, M., Kapahi, P.  (2009). Aging is RSKy Business.  Science 236, 55.

Kaeberlein, M. (2009). Spermidine surprise for long life (2009) Nature Cell Biology 11, 1277.

Kaeberlein, M. (2010). Sirtuins. McGraw Hill 2010 Yearbook of Science & Technology.

Kaeberlein, M., Shamieh, L. S.  (2010). The role of TOR signaling in aging. Comparative Biology of Aging. N. Wolf (Ed.)

Mehta, R., Chandler-Brown, D., Ramos, F. J., Shamieh, L. S., Kaeberlein, M. (2010)  Regulation of mRNA translation as a conserved mechanism of longevity control.  Protein Metabolism and Homeostasis in Aging.  N. Tavernarakis (Ed.)

Kaeberlein, M. (2010).  Resveratrol and rapamycin: Are they anti-aging drugs?  BioEssays 32, 96.

Olson, B. A., Murakami, C. J., Kaeberlein, M. (2010). YODA: Software to facilitate high-throughput analysis of chronological life span, growth rate, and survival in budding yeast. BMC Bioinformatics 11, 141.

Kaeberlein, M. (2010). Lessons on longevity from the budding yeast.  Nature 464, 513-519.

Leiser, S. L., Kaeberlein, M. (2010).  A role for SIRT1 in the hypoxic response.  Mol Cell. 38, 779-780.

Mehta, R., Chandler-Brown, D., Ramos, F. J., Shamieh, L. S., Kaeberlein, M. (2010).  Regulation of mRNA translation as a conserved mechanism of longevity control. Adv Exp Med Biol. 694,14-29.

Leiser, S. L., Kaeberlein, M. (2010). The hypoxia inducible factor HIF-1 functions as both a positive and negative modulator of aging.  Biol Chem. 391, 1131

Choi, H. R., Cho, K. A., Kang, H. T., Lee, J. B. Kaeberlein, M., Suh, Y., Chung, K., Park, S. C. (2011). Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix.  Aging Cell. 10, 148-57.

Sutphin, G. L., Olsen, B. A., Kennedy, B. K., Kaeberlein, M. (2011). Genome-wide analysis of aging in yeast.  Aging Research in Yeast.  M. Breitenbach, S. M. Jazwinski, P. Laun (Eds.)

Kaeberlein, M. and Kennedy, B. K. (2011).  Hot topics in aging research: Protein translation and TOR signaling, 2010.  Aging Cell. 10, 185-190

Sutphin, G. L., Kaeberlein, M.  (2011).  Comparative genetics of aging. Handbook of the Biology of Aging, 7th Edition.  E.J. Masoro and S. N. Austad (Eds.)

Kaeberlein, M., Kennedy, B. K., Liu, X., Suh, Y., Zhou, Z. (2011)  Trinations aging symposium.  Mech Age Dev. 132, 348-352.

Delaney, J. R., Murakami, C. J., Olsen, B., Kennedy, B. K., Kaeberlein, M. (2011). Quantitative evidence for fitness defects from 32 longevity-associated alleles in yeast.  Cell Cycle 10, 156-165.

Burtner,C. R., Murakami, C. J., Olsen, B., Kennedy, B. K., Kaeberlein, M. (2011). A genomic analysis of chronological longevity factors in yeast. Cell Cycle 10, 1385-1396.

Leiser, S. F., Begun, A., Kaeberlein, M. (2011). HIF-1 modulates longevity and healthspan in a temperature-dependent manner.  Aging Cell 10, 318-326.

Murakami, C. J., Wall, V., Basisty, N., Kaeberlein, M. (2011). Composition and acidification of the culture medium influences chronological aging similarly in vineyard and laboratory yeast. PLoS One 6, e24530.

Burnett, C., Valentini, S., Cabreiro, F., Goss, M., Somogyvári. M., Piper, M. D., Hoddinott, M., Sutphin, G. L., Leko, V., McElwee, J. J., Vazquez-Manrique, R. P., Orfila, A. M., Ackerman, D., Au, C., Vinti, G., Riesen, M., Howard, K., Neri, C., Bedalov, A., Kaeberlein, M., Soti, C., Partridge, L., Gems, D. (2011). Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature 477, 482-485.

Kruegel, U., Robison, B., Dange, T., Kahlert, G., Delaney, J. R., Kotireddy, S., Tsuchiya, M., Tsuchiyama, S., Murakami, C. J., Schleit, J., Sutphin, G., Carr, D., Tar, K., Dittmar, G., Kaeberlein, M., Kennedy, B. K., Schmidt, M. (2011). Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae. PLoS Genet 7, e1002253.

Delaney, J. R., Sutphin, G. L., Dulken, B., Sim, S., Kim, J. R., Robison, B., Schleit, J., Murakami, C. J., Carr, D., An, E. H., Choi, E., Chou, A., Fletcher, M., Jelic, M., Liu, B., Lockshon, D., Moller, R. M., Pak, D. N., Peng, Q., Peng, Z. J., Pham, K. M., Sage, M., Solanky, A., Steffen, K. K., Tsuchiya, M., Tsuchiyama, S., Johnson, S., Raabe, C., Suh, Y., Zhou, Z., Liu, X., Kennedy, B. K., Kaeberlein, M. (2011). Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Aging Cell 10, 1089-1091.

Schleit, J., Wall, V. Z., Simko, M., Kaeberlein, M. (2011). The MDT-15 Subunit of Mediator Interacts with Dietary Restriction to Modulate Longevity and Fluoranthene Toxicity in Caenorhabditis elegans. PLoS One 6, e28036.

Sutphin, G. L., Olsen, B. A., Kennedy, B. K., Kaeberlein, M. (2012). Genome-wide analysis of yeast aging. Subcell Biochem 57, 251-289.

Kaeberlein, M., Kennedy, B. K. (2012).  A new chronological aging assay. Cell Cycle 11.

Steffen KK, McCormick MA, Pham KM, Mackay VL, Delaney JR, Murakami CJ, Kaeberlein M, Kennedy BK (2012). Ribosome Deficiency Protects Against ER Stress in Saccharomyces cerevisiae. 2012 Feb;.
Kaeberlein M (2012). Hypertrophy and senescence factors in yeast aging. A reply to Bilinski et al. FEMS Yeast Res.. 2012 May; 12(3):269-70.
Zhou B, Yang L, Li S, Huang J, Chen H, Hou L, Wang J, Green CD, Yan Z, Huang X, Kaeberlein M, Zhu L, Xiao H, Liu Y, Han JD (2012). Midlife gene expressions identify modulators of aging through dietary interventions.. 2012 Apr;.