Projects in the Kaeberlein lab have a common theme centered on identifying the genetic and environmental factors that modulate longevity and understanding how these factors act at a molecular level. We use three different model organisms for our research and work in collaboration with several other labs to accomplish our goals. Descriptions of the current projects in the lab can be found below.
The budding yeast Saccharomyces cerevisiae is the premier single-celled aging model. Our yeast projects include:
The nematode Caenorhabditis elegans is the best studied invertebrate aging model. Our C. elegans projects include:
The Kaeberlein lab works in collabroation with the Consortium for the Determination of Public Pathways Regulating Longevity to test whether mouse orthologs of yeast/worm aging genes regulate life span similarly in mammals.
The Kaeberlein Lab is interested in developing computational tools and resources that will facilitate our own research and be of value to the broader gerontological community. See the "Resources" section of our website for software that has been previously made available.