Zhou B, Yang L, Li S, Huang J, Chen H, Hou L, Wang J, Green CD, Yan Z, Huang X, Kaeberlein M, Zhu L, Xiao H, Liu Y, Han JD (2012). Midlife gene expressions identify modulators of aging through dietary interventions.. 2012 Apr;.
Kaeberlein M (2012). Hypertrophy and senescence factors in yeast aging. A reply to Bilinski et al. FEMS Yeast Res.. 2012 May; 12(3):269-70.
Steffen KK, McCormick MA, Pham KM, Mackay VL, Delaney JR, Murakami CJ, Kaeberlein M, Kennedy BK (2012). Ribosome Deficiency Protects Against ER Stress in Saccharomyces cerevisiae. 2012 Feb;.
Kaeberlein M, Kennedy BK (2012). A new chronological survival assay in mammalian cell culture. Cell Cycle. 2012 Jan; 11(2):201-2.
Sutphin GL, Olsen BA, Kennedy BK, Kaeberlein M (2012). Genome-wide analysis of yeast aging. Subcell. Biochem.. 2012 ; 57:251-89.
Delaney JR, Sutphin GL, Dulken B, Sim S, Kim JR, Robison B, Schleit J, Murakami CJ, Carr D, An EH, Choi E, Chou A, Fletcher M, Jelic M, Liu B, Lockshon D, Moller RM, Pak DN, Peng Q, Peng ZJ, Pham KM, Sage M, Solanky A, Steffen KK, Tsuchiya M, Tsuchiyama S, Johnson S, Raabe C, Suh Y, Zhou Z, Liu X, Kennedy BK, Kaeberlein M (2011). Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Aging Cell. 2011 Dec; 10(6):1089-91.
Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvári M, Piper MD, Hoddinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez-Manrique RP, Orfila AM, Ackerman D, Au C, Vinti G, Riesen M, Howard K, Neri C, Bedalov A, Kaeberlein M, Soti C, Partridge L, Gems D (2010). Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature. 2011 Sep; 477(7365):482-5.
Murakami CJ, Wall V, Basisty N, Kaeberlein M (2011). Composition and acidification of the culture medium influences chronological aging similarly in vineyard and laboratory yeast. PLoS ONE. 2011 ; 6(9):e24530.
Kruegel U, Robison B, Dange T, Kahlert G, Delaney JR, Kotireddy S, Tsuchiya M, Tsuchiyama S, Murakami CJ, Schleit J, Sutphin G, Carr D, Tar K, Dittmar G, Kaeberlein M, Kennedy BK, Schmidt M (2011). Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae. PLoS Genet.. 2011 Sep; 7(9):e1002253.
Schleit J, Wall VZ, Simko M, Kaeberlein M (2011). The MDT-15 Subunit of Mediator Interacts with Dietary Restriction to Modulate Longevity and Fluoranthene Toxicity in Caenorhabditis elegans.. PLoS ONE. 2011 ; 6(11):e28036.
Kaeberlein M, Kennedy BK, Liu X, Suh Y, Zhou Z (2011). Trinations aging symposium. 2011 Jul.
Burtner CR, Murakami CJ, Olsen B, Kennedy BK, Kaeberlein M (2011). A genomic analysis of chronological longevity factors in budding yeast. Cell Cycle. 2011 May; 10(9):1385-96.
Leiser SF, Begun A, Kaeberlein M (2011). HIF-1 modulates longevity and healthspan in a temperature-dependent manner.. Aging Cell. 2011 Apr; 10(2):318-26.
Kaeberlein M, Kennedy BK (2011). Hot topics in aging research: protein translation and TOR signaling, 2010.. Aging Cell. 2011 Apr; 10(2):185-90.
Delaney JR, Murakami CJ, Olsen B, Kennedy BK, Kaeberlein M (2011). Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast. Cell Cycle. 2011 Jan; 10(1):156-65.
Sutphin, GL, Kaeberlein, M. (2011). Comparative genetics of aging. in Handbook of the Biology of Aging, 7th Edition. E.J. Masoro and S. N. Austad (Eds.)
Choi HR, Cho KA, Kang HT, Lee JB, Kaeberlein M, Suh Y, Chung IK, Park SC (2010). Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix. Aging Cell. 2011 Feb; 10(1):148-57.
Mehta R, Chandler-Brown D, Ramos FJ, Shamieh LS, Kaeberlein M (2010). Regulation of mRNA translation as a conserved mechanism of longevity control. Adv. Exp. Med. Biol.. 2010 ; 694:14-29.
Leiser SF, Kaeberlein M (2010). The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging. Biol. Chem. 2010 Oct; 391(10):1131-7.
Leiser SF, Kaeberlein M (2010). A role for SIRT1 in the hypoxic response. Mol. Cell. 2010 Jun; 38(6):779-80.
Kaeberlein, M., Shamieh, LS. (2010). The role of TOR signaling in aging. in Comparative Biology of Aging. N. Wolf (Ed.)
Kaeberlein, M. (2010). Lessons on longevity from budding yeast. Nature 464, 513-519. Download PDF
Olsen B, Murakami CJ, Kaeberlein M. (2010). YODA: Software to facilitate high-throughput analysis of chronological life span, growth rate, and survival in budding yeast. BMC Bioinformatics 11:141.
Kaeberlein M (2010). Resveratrol and rapamycin: are they anti-aging drugs? Bioessays. 2010 Feb; 32(2):96-9.
Mehta, R, Chandler-Brown, D, Ramos, FJ, Shamieh, LS, Kaeberlein, M. (2010) Regulation of mRNA translation as a conserved mechanism of longevity control. in Protein Metabolism and Homeostasis in Aging. N. Tavernarakis (Ed.)
Kaeberlein, M. (2009). Sirtuins. McGraw Hill 2010 Yearbook of Science & Technology.
Kaeberlein M (2009). Spermidine surprise for a long life.. Nat. Cell Biol. 2009 Nov; 11(11):1277-8.
Kaeberlein M, Kapahi P (2009). Cell signaling. Aging is RSKy business. Science. 2009 Oct; 326(5949):55-6.
Enns LC, Morton JF, Mangalindan RS, McKnight GS, Schwartz MW, Kaeberlein MR, Kennedy BK, Rabinovitch PS, Ladiges WC (2009). Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A. J. Gerontol. A Biol. Sci. Med. Sci.. 2009 Dec; 64(12):1221-31.
Kennedy BK, Kaeberlein M (2009). Hot topics in aging research: protein translation, 2009. Aging Cell. 2009 Dec; 8(6):617-23.
Kaeberlein M, Kapahi P (2009). The hypoxic response and aging. Cell Cycle. 2009 Aug; 8(15):2324.
Kaeberlein M, Kennedy BK (2009). Ageing: A midlife longevity drug? Nature. 2009 Jul; 460(7253):331-2.
Steffen KK, Kennedy BK, Kaeberlein M (2009). Measuring replicative life span in the budding yeast. J Vis Exp. 2009 ;(28).
Burtner, C. R., Murakami C. J., Kaeberlein, M. (2009). A genomic approach to yeast chronological aging. Methods Mol Biol 548, 101-114. Download PDF
Dang, W., Steffen, K. K., Perry, R., Dorsey, J. A., Johnson, F. B., Shilatifard A., Kaeberlein, M., Kennedy, B. K., Berger, S. L. (2009). Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature 459, 802-807. Download PDF
Mehta, R., Steinkraus, K.A., Sutphin, G.L., Ramos, F.J., Shamieh, L.S., Huh, A., Davis, C., Chandler-Brown, D., Kaeberlein, M. (2009). Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans. Science 324, 1196-1198. Download PDF
Sutphin, G. L., Kaeberlein, M. (2009). Measuring Ceanorhabditis elegans life span on solid media . J Vis Exp May 12;(27). pii: 1152. doi: 10.3791/1152. Download Video and PDF
Murakami, C., Kaeberlein, M. (2009). Quantifying yeast chronological life span by outgrowth of aged cells. J Vis Exp May 6;(27). pii: 1156. doi: 10.3791/1156. Download Video and PDF
Burtner, C.R., Murakami, C.J., Kennedy, B.K., Kaeberlein, M. (2009). A molecular mechanism of chronological aging in yeast. Cell Cycle. 8(8), 1256-70. Download PDF
Kaeberlein, M. and Kennedy, B.K. (2008). Hot topics protein translation, 2008. Aging Cell 7, 777-782. Download PDF
Managbanag, J. R., Witten, T. M., Bonchev, D., Fox, L. A., Tsuchiya, M., Kennedy, B.K. and Kaeberlein, M. (2008). Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity . PLoS One 3, e3802. Download PDF
Steinkraus, K. A., Kaeberlein, M. and Kennedy, B.K. (2008). Replicative aging in yeast: the means to the end. Ann Rev Cell Dev Biol 24, 29-54. Download PDF
Kaeberlein, M. (2008). A molecular age barrier. Nature 454, 709-710. Download PDF
Kaeberlein, M. (2008). The ongoing saga of sirtuins and aging. Cell Metab 8, 4-5. Download PDF
Smith, E.D., Kaeberlein, T.L., Lydum, B.T., Welton, K.L., Kennedy, B.K., Fox, L.A., and Kaeberlein, M. (2008). Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans. BMC Dev Biol 8, 49. Download PDF
Steffen, K.K., MacKay, V.L., Kerr, E.O., Tsuchiya, M., Hu, D., Fox, L.A., Dang, N., Johnston, E.D., Oakes, J.A., Tchao, B.N., Pak, D.N., Fields, S.F., Kennedy, B.K., and Kaeberlein, M. (2008). Yeast life span extension by depletion of 60S ribosomal subunits is mediated by Gcn4. Cell 133, 292-302. Download PDF
Smith, E.D., Tsuchiya, M., Fox, L.A., Dang, N., Hu, D., Kerr, E.O., Johnston, E.D., Tchao, B.N., Pak, D.N., Welton, K.L., et al. (2008). Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome Research 18, 564-570. Download PDF
Effros, R.B., Austad, S., Blau, H., Chesselet, M.F., Ingram, D., Johnson, T.E., Kaeberlein, M., Lundblad, V., McCarter, R., McElhaney, J., and Saag, M. (2008). The biological sciences section program at the 60th annual meeting of the gerontological society of america. J. Gerontol. 63, 331-337. Download PDF
Steinkraus KA, Smith ED, Davis C, Carr D, Pendergrass WR, Sutphin GL, Kennedy BK, Kaeberlein M (2008). Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans.. Aging Cell. 2008 Jun; 7(3):394-404.
Schmidlin T., Kaeberlein M., Kudlow B. A., Mackay V., Lockshon D., Kennedy B. K. (2008) Single-gene deletions that restore mating competence to diploid yeast. FEMS Yeast Res. 8, 276-286. Download PDF
Sutphin, G.L., Kaeberlein M. (2008) Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes. Exp Gerontol. 43, 130-135. Download PDF
Murakami, C.J., Burtner, C.R., Kennedy, B.K., Kaeberlein, M. (2008) A method for high-throughput quantitative analysis of yeast chronological life span. J. Gerontol. 63, 113-121. Download PDF
Kaeberlein M., Kennedy, B. K. (2007) Protein translation, 2007 Aging Cell 6, 731-734. Download PDF
Kaeberlein M. (2007) Molecular basis of ageing. EMBO Rep 8, 907-911. Download PDF
Kaeberlein M., Powers, R. W. (2007). Sir2 and calorie restriction in yeast: A skeptical perspective. Age Res Rev 6, 128-140. Download PDF
Kaeberlein M., Kennedy, B. K. (2007). Does resveratrol activate yeast Sir2 in vivo. Aging Cell 6, 415-416. Download PDF
Kennedy B. K., Steffen, K. K., Kaeberlein M. (2007). Ruminations on dietary restriction and aging. Cell Mol Life Sci 64, 1323-1328. Download PDF
Kaeberlein M., Burtner, C. R., Kennedy, B. K. (2007). Recent developments in yeast aging. PLoS Genet 3, e84. Download PDF
Kaeberlein M. (2007). Longevity genomics across species. Current Genomics 8, 73-78. Download PDF
Smith E. D., Kennedy B. K., Kaeberlein M. (2007). Genome-wide identification of conserved longevity genes in yeast and worms.. Mech Ageing Dev 128, 106-111. Download PDF
Lockshon, D., Surface, L. E., Kerr, E. O., Kaeberlein M., Kennedy B. K., (2007). The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function. Genetics 175, 77-91. Download PDF
Tsuchiya, M, Dang, N., Kerr, E. O., Hu, D., Steffan, K. K., Oakes, J. A., Kennedy B. K., Kaeberlein M. (2006). Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast.. Aging Cell 5, 505-514. Download PDF
Kaeberlein T. L. , Smith E. D., Tsuchiya M., Welton K. L., Thomas J. H., Fields S., Kennedy B. K., Kaeberlein M. (2006). Lifespan extension in Caenorhabditis elegans by complete removal of food. Aging Cell 5, 487-494. Download PDF
Kaeberlein, M., Rabinovitch, P. S. (2006). Grapes versus gluttony. Nature 444, 280-281. Download PDF
Kaeberlein, M., Steffen, K. K., Hu, D., Dang, N., Kerr, E. O., Tsuchiya, M., Fields, S., and Kennedy, B. K. (2006). Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction". Science 312, 1312; author reply 1312. Download PDF
Kaeberlein, M. (2006). Genome-wide approaches to understanding human aging. Human Genomics 2, 422-428. Download PDF
Kaeberlein, M., Hu, D., Kerr, E. O., Tsuchiya, M., Westman, E. A., Dang, N., Fields, S., and Kennedy, B. K. (2006). Author's Reply. PLoS Genet 2, e34. Download PDF
Kaeberlein, M. (2006). Longevity and aging in the budding yeast. In Handbook of models for human aging, P. M. Conn, ed. (Boston, Elsevier Press), pp. 109-120.
Kaeberlein, M. (2006). Application of high-throughput technologies to aging-related research. In Handbook of models for human aging, P. M. Conn, ed. (Boston, Elsevier Press), pp. 207-218.
Powers, R. W., 3rd, Kaeberlein, M., Caldwell, S. D., Kennedy, B. K., and Fields, S. (2006). Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev 20, 174-184. Download PDF
Hudson, F. N., Kaeberlein, M., Linford, N., Pritchard, D., Beyer, R. P., and Rabinovitch, P. S., eds. (2005). Microarray analysis of gene expression changes in aging. In Handbook of the Biology of Aging, 6th edn (Academic Press).
Kaeberlein, M., Powers, R. W., 3rd, Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., and Kennedy, B. K. (2005). Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310, 1193-1196. Download PDF
Kennedy, B. K., Smith, E. D., and Kaeberlein, M. (2005). The enigmatic role of Sir2 in aging. Cell 123, 548-550. Download PDF
Kaeberlein, M., Hu, D., Kerr, E. O., Tsuchiya, M., Westman, E. A., Dang, N., Fields, S., and Kennedy, B. K. (2005). Increased Life Span due to Calorie Restriction in Respiratory-Deficient Yeast. PLoS Genet 1, e69. Download PDF
Kaeberlein, M., McDonagh, T., Heltweg, B., Hixon, J., Westman, E. A., Caldwell, S. D., Napper, A., Curtis, R., DiStefano, P. S., Fields, S., et al. (2005). Substrate-specific activation of sirtuins by resveratrol. J Biol Chem 280, 17038-17045. Download PDF
Kaeberlein, M., Kirkland, K. T., Fields, S., and Kennedy, B. K. (2005). Genes determining yeast replicative life span in a long-lived genetic background. Mech Ageing Dev 126, 491-504. Download PDF
Kaeberlein, M., and Kennedy, B. K. (2005). Large-scale identification in yeast of conserved ageing genes. Mech Ageing Dev 126, 17-21. Download PDF
Kaeberlein, M., Kirkland, K. T., Fields, S., and Kennedy, B. K. (2004). Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol 2, E296. Download PDF