Lab Publications

2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004

2016

Leiser SF, Jafari G, Primitivo M, Sutphin GL, Dong J, Leonard A, Fletcher M, Kaeberlein M (2016). Age-associated vulval integrity is an important marker of nematode healthspan. Age (Dordr). 2016 Aug;.

Bitto A, Ito TK, Pineda VV, LeTexier NJ, Huang HZ, Sutlief E, Tung H, Vizzini N, Chen B, Smith K, Meza D, Yajima M, Beyer RP, Kerr KF, Davis DJ, Gillespie CH, Snyder JM, Treuting PM, Kaeberlein M (2016). Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice. Elife. 2016 ; 5.

Johnson SC, Kaeberlein M (2016). Rapamycin in aging and disease: maximizing efficacy while minimizing side effects. Oncotarget. 2016 Jul;.

Johnson SC, Kaeberlein M (2016). Rapamycin in aging and disease: maximizing efficacy while minimizing side effects. Oncotarget. 2016 Jul;.

Kaeberlein M, Creevy KE, Promislow DE (2016). The dog aging project: translational geroscience in companion animals. Mamm. Genome. 2016 Aug; 27(7-8):279-88.

Leiser SF, Rossner R, Kaeberlein M (2016). New insights into cell non-autonomous mechanisms of the C. elegans hypoxic response. Worm. ; 5(2):e1176823.

Jafari G, Wasko BM, Kaeberlein M, Crofts AR (2016). New functional and biophysical insights into the mitochondrial Rieske iron-sulfur protein from genetic suppressor analysis in C. elegans. Worm. ; 5(2):e1174803.

Chen KL, Crane MM, Kaeberlein M (2016). Microfluidic technologies for yeast replicative lifespan studies. Mech. Ageing Dev.. 2016 Mar;.

Sunshine AB, Ong GT, Nickerson DP, Carr D, Murakami CJ, Wasko BM, Shemorry A, Merz AJ, Kaeberlein M, Dunham MJ (2015). Aneuploidy shortens replicative lifespan in Saccharomyces cerevisiae. Aging Cell. 2016 Apr; 15(2):317-24.

2015

Kaeberlein, M, Rabinovitch PS, Martin GM (2015).  Healthy aging: The Ultimate Preventative Medicine. Science 350:1191. [Download free text here] [Download PDF here]

Leiser SF, Miller H, Rossner R, Fletcher M, Leonard A, Primitivo M, Rintala N, Ramos FJ, Miller DL, Kaeberlein M (2015). Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span. Science. 2015 Nov 19.  [Download free text here]

Bitto A, Wang AM, Bennett CF, Kaeberlein M (2015). Biochemical Genetic Pathways that Modulate Aging in Multiple Species. Cold Spring Harb Perspect Med. 2015 5(11).

Chandler-Brown D, Choi H, Park S, Ocampo BR, Chen S, Le A, Sutphin GL, Shamieh LS, Smith ED, Kaeberlein M (2015). Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans. Front Genet. 6:316.

Jafari G, Wasko BM, Tonge A, Schurman N, Dong C, Li Z, Peters R, Kayser EB, Pitt JN, Morgan PG, Sedensky MM, Crofts AR, Kaeberlein M (2015). Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron-sulfur protein. Proc. Natl. Acad. Sci. U.S.A.. 2015 Nov; 112(45):E6148-57.

Yang J, McCormick MA, Zheng J, Xie Z, Tsuchiya M, Tsuchiyama S, El-Samad H, Ouyang Q, Kaeberlein M, Kennedy BK, Li H (2015). Systematic analysis of asymmetric partitioning of yeast proteome between mother and daughter cells reveals "aging factors" and mechanism of lifespan asymmetry. Proc. Natl. Acad. Sci. U.S.A.. 2015 Sep; 112(38):11977-82.

Vermulst M, Denney AS, Lang MJ, Hung CW, Moore S, Mosely AM, Thompson WJ, Madden V, Gauer J, Wolfe KJ, Summers DW, Schleit J, Sutphin GL, Haroon S, Holczbauer A, Caine J, Jorgenson J, Cyr D, Kaeberlein M, Strathern JN, Duncan MC, Erie DA (2015). Transcription errors induce proteotoxic stress and shorten cellular lifespan. Nat Commun. 2015 ; 6:8065.

Johnson SC, Yanos ME, Bitto A, Castanza A, Gagnidze A, Gonzalez B, Gupta K, Hui J, Jarvie C, Johnson BM, Letexier N, McCanta L, Sangesland M, Tamis O, Uhde L, Van Den Ende A, Rabinovitch PS, Suh Y, Kaeberlein M (2015). Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice. Front Genet. 2015 ; 6:247.

Sen P, Dang W, Donahue G, Dai J, Dorsey J, Cao X, Liu W, Cao K, Perry R, Lee JY, Wasko BM, Carr DT, He C, Robison B, Wagner J, Gregory BD, Kaeberlein M, Kennedy BK, Boeke JD, Berger SL (2015). H3K36 methylation promotes longevity by enhancing transcriptional fidelity. Genes Dev.. 2015 Jul; 29(13):1362-76.

Kaeberlein M (2015). The Biology of Aging: Citizen Scientists and Their Pets as a Bridge Between Research on Model Organisms and Human Subjects. Vet. Pathol.. 2015 Jun;.

Cui HJ, Liu XG, McCormick M, Wasko BM, Zhao W, He X, Yuan Y, Fang BX, Sun XR, Kennedy BK, Suh Y, Zhou ZJ, Kaeberlein M, Feng WL (2014). PMT1 deficiency enhances basal UPR activity and extends replicative lifespan of Saccharomyces cerevisiae. Age (Dordr). 2015 Jun; 37(3):9788.

Pitt JN, Kaeberlein M (2015). Why Is Aging Conserved and What Can We Do about It?. PLoS Biol.. 2015 Apr; 13(4):e1002131.

McCormick MA, Delaney JR, Tsuchiya M, Tsuchiyama S, Shemorry A, Sim S, Chou AC, Ahmed U, Carr D, Murakami CJ, Schleit J, Sutphin GL, Wasko BM, Bennett CF, Wang AM, Olsen B, Beyer RP, Bammler TK, Prunkard D, Johnson SC, Pennypacker JK, An E, Anies A, Castanza AS, Choi E, Dang N, Enerio S, Fletcher M, Fox L, Goswami S, Higgins SA, Holmberg MA, Hu D, Hui J, Jelic M, Jeong KS, Johnston E, Kerr EO, Kim J, Kim D, Kirkland K, Klum S, Kotireddy S, Liao E, Lim M, Lin MS, Lo WC, Lockshon D, Miller HA, Moller RM, Muller B, Oakes J, Pak DN, Peng ZJ, Pham KM, Pollard TG, Pradeep P, Pruett D, Rai D, Robison B, Rodriguez AA, Ros B, Sage M, Singh MK, Smith ED, Snead K, Solanky A, Spector BL, Steffen KK, Tchao BN, Ting MK, Vander Wende H, Wang D, Welton KL, Westman EA, Brem RB, Liu XG, Suh Y, Zhou Z, Kaeberlein M, Kennedy BK (2015). A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging. Cell Metab.. 2015 Nov; 22(5):895-906.

Xiong XD, Jung HJ, Gombar S, Park JY, Zhang CL, Zheng H, Ruan J, Li JB, Kaeberlein M, Kennedy BK, Zhou Z, Liu X, Suh Y (2015). MicroRNA transcriptome analysis identifies miR-365 as a novel negative regulator of cell proliferation in Zmpste24-deficient mouse embryonic fibroblasts. Mutat. Res.. 2015 Jul; 777:69-78.

Wang AM, Promislow DE, Kaeberlein M (2015). Fertile waters for aging research. Cell. 2015 Feb; 160(5):814-5.

Cho S, Cho M, Kim J, Kaeberlein M, Lee SJ, Suh Y (2014). Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism. Oncotarget. 2015 Jan; 6(1):43-55.

2014

He C, Tsuchiyama SK, Nguyen QT, Plyusnina EN, Terrill SR, Sahibzada S, Patel B, Faulkner AR, Shaposhnikov MV, Tian R, Tsuchiya M, Kaeberlein M, Moskalev AA, Kennedy BK, Polymenis M (2014). Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import. PLoS Genet.. 2014 Dec; 10(12):e1004860.

Johnson SC, Sangesland M, Kaeberlein M, Rabinovitch PS (2014). Modulating mTOR in Aging and Health. Interdiscip Top Gerontol. 2015; 40:107-27.

Sutphin GL, Delaney JR, Kaeberlein M (2014). Replicative life span analysis in budding yeast. Methods Mol. Biol.. 2014 ; 1205:341-57.

Burman JL, Itsara LS, Kayser EB, Suthammarak W, Wang AM, Kaeberlein M, Sedensky MM, Morgan PG, Pallanck LJ (2014). A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer. Dis Model Mech. 2014 Oct; 7(10):1165-74.

McCormick MA, Mason AG, Guyenet SJ, Dang W, Garza RM, Ting MK, Moller RM, Berger SL, Kaeberlein M, Pillus L, La Spada AR, Kennedy BK (2014). The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction. Cell Rep. 2014 Jul; 8(2):477-86.

Bitto A, Kaeberlein M (2014). Rejuvenation: it's in our blood. Cell Metab.. 2014 Jul; 20(1):2-4.

Bennett CF, Vander Wende H, Simko M, Klum S, Barfield S, Choi H, Pineda VV, Kaeberlein M (2014). Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans. Nat Commun. 2014 ; 5:3483.

Kaeberlein M (2014). Rapamycin and ageing: when, for how long, and how much?. J Genet Genomics. 41(9):459-63.

Bennett CF, Kaeberlein M (2014). The mitochondrial unfolded protein response and increased longevity: cause, consequence, or correlation?. Exp. Gerontol.. 2014 Aug; 56:142-6.

Promislow DE, Kaeberlein M (2014). Development. Chemical warfare in the battle of the sexes. Science. 2014 Jan; 343(6170):491-2.

Zhao W, Fang BX, Niu YJ, Liu YN, Liu B, Peng Q, Li JB, Wasko BM, Delaney JR, Kennedy BK, Suh Y, Zhou ZJ, Kaeberlein M, Liu XG (2014). Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase. Mech. Ageing Dev. 2014 Jan;.

Labunskyy VM, Gerashchenko MV, Delaney JR, Kaya A, Kennedy BK, Kaeberlein M, Gladyshev VN (2014). Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response. PLoS Genet. 2014 Jan; 10(1):e1004019.

2013

Choi H, Schneider H, Klum S, Chandler-Brown D, Kaeberlein M, Shamieh L (2013). UV-Photoconversion of Ethosuximide from a Longevity-Promoting Compound to a Potent Toxin. PLoS ONE. 2013 ; 8(12):e82543.

Kaeberlein M (2013). mTOR Inhibition: From Aging to Autism and Beyond. Scientifica (Cairo). 2013 ; 2013:849186.

Johnson SC, Martin GM, Rabinovitch PS, Kaeberlein M (2013). Preserving youth: does rapamycin deliver?. Sci Transl Med. 2013 Nov; 5(211):211fs40. [Full Text] [PDF]

Johnson SC, Yanos ME, Kayser EB, Quintana A, Sangesland M, Castanza A, Uhde L, Hui J, Wall VZ, Gagnidze A, Oh K, Wasko BM, Ramos FJ, Palmiter RD, Rabinovitch PS, Morgan PG, Sedensky MM, Kaeberlein M (2013). mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome. Science. 2013 Dec; 342(6165):1524-8. [Abstract] [Full Text]

Wasko BM, Carr DT, Tung H, Doan H, Schurman N, Neault JR, Feng J, Lee J, Zipkin B, Mouser J, Oudanonh E, Nguyen T, Stetina T, Shemorry A, Lemma M, Kaeberlein M (2013). Buffering the pH of the culture medium does not extend yeast replicative lifespan. F1000Res. 2013 ; 2:216.

Wasko BM, Kaeberlein M (2013). Yeast replicative aging: A paradigm for defining conserved longevity interventions. FEMS Yeast Res.. 2013 Oct;.

Wasko BM, Carr DT, Tung H, Doan H, Schurman N, Neault JR, Feng J, Lee J, Zipkin B, Mouser J, Oudanonh E, Nguyen T, Stetina T, Shemorry A, Lemma M, Kaeberlein M (2013). Buffering the pH of the culture medium does not extend yeast replicative lifespan. F1000Res. 2013 ; 2:216.

Kaeberlein M (2013). mTOR Inhibition: From Aging to Autism and Beyond. Scientifica (Cairo). 2013 ; 2013:849186.

Kaeberlein M (2013). Deciphering the role of natural variation in age-related protein homeostasis. BMC Biol.. 2013 ; 11:102.

O'Leary MN, Schreiber KH, Zhang Y, Duc AC, Rao S, Hale JS, Academia EC, Shah SR, Morton JF, Holstein CA, Martin DB, Kaeberlein M, Ladiges WC, Fink PJ, Mackay VL, Wiest DL, Kennedy BK (2013). The ribosomal protein rpl22 controls ribosome composition by directly repressing expression of its own paralog, rpl22l1. PLoS Genet.. 2013 Aug; 9(8):e1003708.

Schleit J, Johnson SC, Bennett CF, Simko M, Trongtham N, Castanza A, Hsieh EJ, Moller RM, Wasko BM, Delaney JR, Sutphin GL, Carr D, Murakami CJ, Tocchi A, Xian B, Chen W, Yu T, Goswami S, Higgins S, Jeong KS, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Olsen B, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Singh M, Spector BL, Wende HV, An EH, Fletcher M, Jelic M, Rabinovitch PS, Maccoss MJ, Han JD, Kennedy BK, Kaeberlein M (2013). Molecular mechanisms underlying genotype-dependent responses to dietary restriction. Aging Cell. 2013 Jul;.

Dang W, Sutphin GL, Dorsey JA, Otte GL, Cao K, Perry RM, Wanat JJ, Saviolaki D, Murakami CJ, Tsuchiyama S, Robison B, Gregory BD, Vermeulen M, Shiekhattar R, Johnson FB, Kennedy BK, Kaeberlein M, Berger SL (2014). Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response. Cell Metab.. 2014 Jun; 19(6):952-66.

Kwan EX, Foss EJ, Tsuchiyama S, Alvino GM, Kruglyak L, Kaeberlein M, Raghuraman MK, Brewer BJ, Kennedy BK, Bedalov A (2012). A Natural Polymorphism in rDNA Replication Origins Links Origin Activation with Calorie Restriction and Lifespan. PLoS Genet.. 2013 Mar; 9(3):e1003329.

Kaeberlein M (2013). Longevity and aging. F1000Prime Rep. 2013 ; 5:5.

Leiser SF, Fletcher M, Begun A, Kaeberlein M (2013). Life-Span Extension From Hypoxia in Caenorhabditis elegans Requires Both HIF-1 and DAF-16 and Is Antagonized by SKN-1. J. Gerontol. A Biol. Sci. Med. Sci.. 2013 Feb;.

Xian B, Shen J, Chen W, Sun N, Qiao N, Jiang D, Yu T, Men Y, Han Z, Pang Y, Kaeberlein M, Huang Y, Han JD (2013). WormFarm: A quantitative control and measurement device towards automated C. elegans aging analysis. Aging Cell. 2013 Feb;.

Delaney JR, Chou A, Olsen B, Carr D, Murakami C, Ahmed U, Sim S, An EH, Castanza AS, Fletcher M, Higgins S, Holmberg M, Hui J, Jelic M, Jeong KS, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Moller R, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Schleit J, Schuster A, Singh M, Spector BL, Sutphin GL, Wang AM, Wasko BM, Wende HV, Kennedy BK, Kaeberlein M (2012). End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging. FEMS Yeast Res.. 2013 Jan;.

Johnson SC, Rabinovitch PS, Kaeberlein M (2013). mTOR is a key modulator of ageing and age-related disease. Nature. 2013 Jan; 493(7432):338-45.

2012

Liu B, Ghosh S, Yang X, Zheng H, Liu X, Wang Z, Jin G, Zheng B, Kennedy BK, Suh Y, Kaeberlein M, Tryggvason K, Zhou Z (2012). Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria.. Cell Metab. 2012 Dec; 16(6):738-50.

Kaeberlein M (2013). Genomics and genetics of aging. Curr. Genomics. 2012 Nov; 13(7):499.

Delaney JR, Ahmed U, Chou A, Sim S, Carr D, Murakami CJ, Schleit J, Sutphin GL, An EH, Castanza A, Fletcher M, Higgins S, Jelic M, Klum S, Muller B, Peng ZJ, Rai D, Ros V, Singh M, Wende HV, Kennedy BK, Kaeberlein M (2012). Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. Aging Cell. 2013 Feb; 12(1):156-66.

Ramos FJ, Kaeberlein M, Kennedy BK (2012). Elevated MTORC1 signaling and impaired autophagy. Autophagy. 2013 Jan; 9(1):108-9.

Delaney JR, Murakami C, Chou A, Carr D, Schleit J, Sutphin GL, An EH, Castanza AS, Fletcher M, Goswami S, Higgins S, Holmberg M, Hui J, Jelic M, Jeong KS, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Moller R, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Schuster A, Singh M, Spector BL, Wende HV, Wang AM, Wasko BM, Olsen B, Kaeberlein M (2012). Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae. Exp. Gerontol.. 2012 Dec;.

Murakami C, Delaney JR, Chou A, Carr D, Schleit J, Sutphin GL, An EH, Castanza AS, Fletcher M, Goswami S, Higgins S, Holmberg M, Hui J, Jelic M, Jeong KS, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Moller R, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Schuster A, Singh M, Spector BL, Vander Wende H, Wang AM, Wasko BM, Olsen B, Kaeberlein M (2012). pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast. Cell Cycle. 2012 Aug; 11(16):3087-96.

Ramos FJ, Chen SC, Garelick MG, Dai DF, Liao CY, Schreiber KH, Mackay VL, An EH, Strong R, Ladiges WC, Rabinovitch PS, Kaeberlein M, Kennedy BK (2012). Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival. Sci Transl Med. 2012 Jul; 4(144):144ra103.

Longo VD, Shadel GS, Kaeberlein M, Kennedy B (2012). Replicative and Chronological Aging in Saccharomyces cerevisiae. Cell Metab.. 2012 Jul; 16(1):18-31.

Schleit J, Wasko BM, Kaeberlein M (2012). Yeast as a model to understand the interaction between genotype and the response to calorie restriction. 2012 Jul;.

Ramos FJ, Kaeberlein M (2012). Ageing: A healthy diet for stem cells. Nature. 2012 Jun; 486(7404):477-8.

Zhou B, Yang L, Li S, Huang J, Chen H, Hou L, Wang J, Green CD, Yan Z, Huang X, Kaeberlein M, Zhu L, Xiao H, Liu Y, Han JD (2012). Midlife gene expressions identify modulators of aging through dietary interventions. Proc. Natl. Acad. Sci. U.S.A.. 2012 May; 109(19):E1201-9.

Kaeberlein M (2012). Hypertrophy and senescence factors in yeast aging. A reply to Bilinski et al. FEMS Yeast Res.. 2012 May; 12(3):269-70.

Steffen KK, McCormick MA, Pham KM, MacKay VL, Delaney JR, Murakami CJ, Kaeberlein M, Kennedy BK (2012). Ribosome deficiency protects against ER stress in Saccharomyces cerevisiae. Genetics. 2012 May; 191(1):107-18.

Kaeberlein M, Kennedy BK (2012). A new chronological survival assay in mammalian cell culture. Cell Cycle. 2012 Jan; 11(2):201-2.

2011

Yanos ME, Bennett CF, Kaeberlein M (2012). Genome-Wide RNAi Longevity Screens in Caenorhabditis elegans. Curr. Genomics. 2012 Nov; 13(7):508-18.

Sutphin GL, Olsen BA, Kennedy BK, Kaeberlein M (2012). Genome-wide analysis of yeast aging. Subcell. Biochem.. 2012 ; 57:251-89.

Delaney JR, Sutphin GL, Dulken B, Sim S, Kim JR, Robison B, Schleit J, Murakami CJ, Carr D, An EH, Choi E, Chou A, Fletcher M, Jelic M, Liu B, Lockshon D, Moller RM, Pak DN, Peng Q, Peng ZJ, Pham KM, Sage M, Solanky A, Steffen KK, Tsuchiya M, Tsuchiyama S, Johnson S, Raabe C, Suh Y, Zhou Z, Liu X, Kennedy BK, Kaeberlein M (2011). Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Aging Cell. 2011 Dec; 10(6):1089-91.

Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvári M, Piper MD, Hoddinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez-Manrique RP, Orfila AM, Ackerman D, Au C, Vinti G, Riesen M, Howard K, Neri C, Bedalov A, Kaeberlein M, Soti C, Partridge L, Gems D (2010). Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature. 2011 Sep; 477(7365):482-5.

Murakami CJ, Wall V, Basisty N, Kaeberlein M (2011). Composition and acidification of the culture medium influences chronological aging similarly in vineyard and laboratory yeast. PLoS ONE. 2011 ; 6(9):e24530.

Kruegel U, Robison B, Dange T, Kahlert G, Delaney JR, Kotireddy S, Tsuchiya M, Tsuchiyama S, Murakami CJ, Schleit J, Sutphin G, Carr D, Tar K, Dittmar G, Kaeberlein M, Kennedy BK, Schmidt M (2011). Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae. PLoS Genet.. 2011 Sep; 7(9):e1002253.

Schleit J, Wall VZ, Simko M, Kaeberlein M (2011). The MDT-15 Subunit of Mediator Interacts with Dietary Restriction to Modulate Longevity and Fluoranthene Toxicity in Caenorhabditis elegans.. PLoS ONE. 2011 ; 6(11):e28036.

Kaeberlein M, Kennedy BK, Liu X, Suh Y, Zhou Z (2011). Trinations aging symposium. 2011 Jul.

Burtner CR, Murakami CJ, Olsen B, Kennedy BK, Kaeberlein M (2011). A genomic analysis of chronological longevity factors in budding yeast. Cell Cycle. 2011 May; 10(9):1385-96.

Leiser SF, Begun A, Kaeberlein M (2011). HIF-1 modulates longevity and healthspan in a temperature-dependent manner.. Aging Cell. 2011 Apr; 10(2):318-26.

Kaeberlein M, Kennedy BK (2011). Hot topics in aging research: protein translation and TOR signaling, 2010.. Aging Cell. 2011 Apr; 10(2):185-90.

Delaney JR, Murakami CJ, Olsen B, Kennedy BK, Kaeberlein M (2011). Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast. Cell Cycle. 2011 Jan; 10(1):156-65.

Sutphin, GL, Kaeberlein, M. (2011). Comparative genetics of aging. in Handbook of the Biology of Aging, 7th Edition.  E.J. Masoro and S. N. Austad (Eds.)

2010

Choi HR, Cho KA, Kang HT, Lee JB, Kaeberlein M, Suh Y, Chung IK, Park SC (2010). Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix. Aging Cell. 2011 Feb; 10(1):148-57.

Mehta R, Chandler-Brown D, Ramos FJ, Shamieh LS, Kaeberlein M (2010). Regulation of mRNA translation as a conserved mechanism of longevity control. Adv. Exp. Med. Biol.. 2010 ; 694:14-29.

Leiser SF, Kaeberlein M (2010). The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging. Biol. Chem. 2010 Oct; 391(10):1131-7.

Leiser SF, Kaeberlein M (2010). A role for SIRT1 in the hypoxic response. Mol. Cell. 2010 Jun; 38(6):779-80.

Kaeberlein, M., Shamieh, LS.  (2010). The role of TOR signaling in aging. in Comparative Biology of Aging. N. Wolf (Ed.)

Kaeberlein, M. (2010). Lessons on longevity from budding yeast. Nature 464, 513-519. Download PDF

Olsen B, Murakami CJ, Kaeberlein M. (2010). YODA: Software to facilitate high-throughput analysis of chronological life span, growth rate, and survival in budding yeast. BMC Bioinformatics 11:141.

Kaeberlein M (2010). Resveratrol and rapamycin: are they anti-aging drugs? Bioessays. 2010 Feb; 32(2):96-9.

Mehta, R, Chandler-Brown, D, Ramos, FJ, Shamieh, LS, Kaeberlein, M. (2010)  Regulation of mRNA translation as a conserved mechanism of longevity control.  in Protein Metabolism and Homeostasis in Aging.  N. Tavernarakis (Ed.)

2009

Kaeberlein, M. (2009). Sirtuins. McGraw Hill 2010 Yearbook of Science & Technology

Kaeberlein M (2009). Spermidine surprise for a long life.. Nat. Cell Biol. 2009 Nov; 11(11):1277-8.

Kaeberlein M, Kapahi P (2009). Cell signaling. Aging is RSKy business. Science. 2009 Oct; 326(5949):55-6.

Enns LC, Morton JF, Mangalindan RS, McKnight GS, Schwartz MW, Kaeberlein MR, Kennedy BK, Rabinovitch PS, Ladiges WC (2009). Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A. J. Gerontol. A Biol. Sci. Med. Sci.. 2009 Dec; 64(12):1221-31.

Kennedy BK, Kaeberlein M (2009). Hot topics in aging research: protein translation, 2009. Aging Cell. 2009 Dec; 8(6):617-23.

Kaeberlein M, Kapahi P (2009). The hypoxic response and aging. Cell Cycle. 2009 Aug; 8(15):2324.

Kaeberlein M, Kennedy BK (2009). Ageing: A midlife longevity drug? Nature. 2009 Jul; 460(7253):331-2.

Steffen KK, Kennedy BK, Kaeberlein M (2009). Measuring replicative life span in the budding yeast. J Vis Exp. 2009 ;(28).

Burtner, C. R., Murakami C. J., Kaeberlein, M. (2009). A genomic approach to yeast chronological aging. Methods Mol Biol 548, 101-114. Download PDF

Dang, W., Steffen, K. K., Perry, R., Dorsey, J. A., Johnson, F. B., Shilatifard A., Kaeberlein, M., Kennedy, B. K., Berger, S. L. (2009). Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature 459, 802-807. Download PDF

Mehta, R., Steinkraus, K.A., Sutphin, G.L., Ramos, F.J., Shamieh, L.S., Huh, A., Davis, C., Chandler-Brown, D., Kaeberlein, M. (2009). Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans. Science 324, 1196-1198. Download PDF

Sutphin, G. L., Kaeberlein, M. (2009). Measuring Ceanorhabditis elegans life span on solid media . J Vis Exp May 12;(27). pii: 1152. doi: 10.3791/1152. Download Video and PDF

Murakami, C., Kaeberlein, M. (2009). Quantifying yeast chronological life span by outgrowth of aged cells. J Vis Exp May 6;(27). pii: 1156. doi: 10.3791/1156. Download Video and PDF

Burtner, C.R., Murakami, C.J., Kennedy, B.K., Kaeberlein, M. (2009). A molecular mechanism of chronological aging in yeast. Cell Cycle. 8(8), 1256-70. Download PDF

2008

Kaeberlein, M. and Kennedy, B.K. (2008). Hot topics protein translation, 2008. Aging Cell 7, 777-782. Download PDF

Managbanag, J. R., Witten, T. M., Bonchev, D., Fox, L. A., Tsuchiya, M., Kennedy, B.K. and Kaeberlein, M. (2008). Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity . PLoS One 3, e3802. Download PDF

Steinkraus, K. A., Kaeberlein, M. and Kennedy, B.K. (2008). Replicative aging in yeast: the means to the end. Ann Rev Cell Dev Biol 24, 29-54. Download PDF

Kaeberlein, M. (2008). A molecular age barrier. Nature 454, 709-710. Download PDF

Kaeberlein, M. (2008). The ongoing saga of sirtuins and aging. Cell Metab 8, 4-5. Download PDF

Smith, E.D., Kaeberlein, T.L., Lydum, B.T., Welton, K.L., Kennedy, B.K., Fox, L.A., and Kaeberlein, M. (2008). Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans. BMC Dev Biol 8, 49. Download PDF

Steffen, K.K., MacKay, V.L., Kerr, E.O., Tsuchiya, M., Hu, D., Fox, L.A., Dang, N., Johnston, E.D., Oakes, J.A., Tchao, B.N., Pak, D.N., Fields, S.F., Kennedy, B.K., and Kaeberlein, M. (2008). Yeast life span extension by depletion of 60S ribosomal subunits is mediated by Gcn4. Cell 133, 292-302. Download PDF

Smith, E.D., Tsuchiya, M., Fox, L.A., Dang, N., Hu, D., Kerr, E.O., Johnston, E.D., Tchao, B.N., Pak, D.N., Welton, K.L., et al. (2008). Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome Research 18, 564-570. Download PDF

Effros, R.B., Austad, S., Blau, H., Chesselet, M.F., Ingram, D., Johnson, T.E., Kaeberlein, M., Lundblad, V., McCarter, R., McElhaney, J., and Saag, M. (2008). The biological sciences section program at the 60th annual meeting of the gerontological society of america. J. Gerontol. 63, 331-337. Download PDF

Steinkraus KA, Smith ED, Davis C, Carr D, Pendergrass WR, Sutphin GL, Kennedy BK, Kaeberlein M (2008). Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans.. Aging Cell. 2008 Jun; 7(3):394-404.

Schmidlin T., Kaeberlein M., Kudlow B. A., Mackay V., Lockshon D., Kennedy B. K. (2008) Single-gene deletions that restore mating competence to diploid yeast. FEMS Yeast Res. 8, 276-286. Download PDF

Sutphin, G.L., Kaeberlein M. (2008) Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes. Exp Gerontol. 43, 130-135. Download PDF

Murakami, C.J., Burtner, C.R., Kennedy, B.K., Kaeberlein, M. (2008) A method for high-throughput quantitative analysis of yeast chronological life span. J. Gerontol. 63, 113-121. Download PDF

2007

Kaeberlein M., Kennedy, B. K. (2007) Protein translation, 2007 Aging Cell 6, 731-734. Download PDF

Kaeberlein M. (2007) Molecular basis of ageing. EMBO Rep 8, 907-911. Download PDF

Kaeberlein M., Powers, R. W. (2007). Sir2 and calorie restriction in yeast: A skeptical perspective. Age Res Rev 6, 128-140. Download PDF

Kaeberlein M., Kennedy, B. K. (2007). Does resveratrol activate yeast Sir2 in vivo. Aging Cell 6, 415-416. Download PDF

Kennedy B. K., Steffen, K. K., Kaeberlein M. (2007). Ruminations on dietary restriction and aging. Cell Mol Life Sci 64, 1323-1328. Download PDF

Kaeberlein M., Burtner, C. R., Kennedy, B. K. (2007). Recent developments in yeast aging. PLoS Genet 3, e84. Download PDF

Kaeberlein M. (2007). Longevity genomics across species. Current Genomics 8, 73-78. Download PDF

Smith E. D., Kennedy B. K., Kaeberlein M. (2007). Genome-wide identification of conserved longevity genes in yeast and worms.. Mech Ageing Dev 128, 106-111. Download PDF

Lockshon, D., Surface, L. E., Kerr, E. O., Kaeberlein M., Kennedy B. K., (2007). The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function. Genetics 175, 77-91. Download PDF

2006

Tsuchiya, M, Dang, N., Kerr, E. O., Hu, D., Steffan, K. K., Oakes, J. A., Kennedy B. K., Kaeberlein M. (2006). Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast.. Aging Cell 5, 505-514. Download PDF

Kaeberlein T. L. , Smith E. D., Tsuchiya M., Welton K. L., Thomas J. H., Fields S., Kennedy B. K., Kaeberlein M. (2006). Lifespan extension in Caenorhabditis elegans by complete removal of food. Aging Cell 5, 487-494. Download PDF

Kaeberlein, M., Rabinovitch, P. S. (2006). Grapes versus gluttony. Nature 444, 280-281. Download PDF

Kaeberlein, M., Steffen, K. K., Hu, D., Dang, N., Kerr, E. O., Tsuchiya, M., Fields, S., and Kennedy, B. K. (2006). Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction". Science 312, 1312; author reply 1312. Download PDF

Kaeberlein, M. (2006). Genome-wide approaches to understanding human aging. Human Genomics 2, 422-428. Download PDF

Kaeberlein, M., Hu, D., Kerr, E. O., Tsuchiya, M., Westman, E. A., Dang, N., Fields, S., and Kennedy, B. K. (2006). Author's Reply. PLoS Genet 2, e34. Download PDF

Kaeberlein, M. (2006). Longevity and aging in the budding yeast. In Handbook of models for human aging, P. M. Conn, ed. (Boston, Elsevier Press), pp. 109-120.

Kaeberlein, M. (2006). Application of high-throughput technologies to aging-related research. In Handbook of models for human aging, P. M. Conn, ed. (Boston, Elsevier Press), pp. 207-218.

Powers, R. W., 3rd, Kaeberlein, M., Caldwell, S. D., Kennedy, B. K., and Fields, S. (2006). Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev 20, 174-184. Download PDF

2005

Hudson, F. N., Kaeberlein, M., Linford, N., Pritchard, D., Beyer, R. P., and Rabinovitch, P. S., eds. (2005). Microarray analysis of gene expression changes in aging. In Handbook of the Biology of Aging, 6th edn (Academic Press).

Kaeberlein, M., Powers, R. W., 3rd, Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., and Kennedy, B. K. (2005). Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310, 1193-1196. Download PDF

Kennedy, B. K., Smith, E. D., and Kaeberlein, M. (2005). The enigmatic role of Sir2 in aging. Cell 123, 548-550. Download PDF

Kaeberlein, M., Hu, D., Kerr, E. O., Tsuchiya, M., Westman, E. A., Dang, N., Fields, S., and Kennedy, B. K. (2005). Increased Life Span due to Calorie Restriction in Respiratory-Deficient Yeast. PLoS Genet 1, e69. Download PDF

Kaeberlein, M., McDonagh, T., Heltweg, B., Hixon, J., Westman, E. A., Caldwell, S. D., Napper, A., Curtis, R., DiStefano, P. S., Fields, S., et al. (2005). Substrate-specific activation of sirtuins by resveratrol. J Biol Chem 280, 17038-17045. Download PDF

Kaeberlein, M., Kirkland, K. T., Fields, S., and Kennedy, B. K. (2005). Genes determining yeast replicative life span in a long-lived genetic background. Mech Ageing Dev 126, 491-504. Download PDF

Kaeberlein, M., and Kennedy, B. K. (2005). Large-scale identification in yeast of conserved ageing genes. Mech Ageing Dev 126, 17-21. Download PDF

2004

Kaeberlein, M., Kirkland, K. T., Fields, S., and Kennedy, B. K. (2004). Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol 2, E296. Download PDF