Identifying HIF-1 Targets that Modulate Aging
Identifying the Cause of Exploding Worms
The Role of Temperature in C. Elegans Longevity
Leiser SF, Miller H, Rossner R, Fletcher M, Leonard A, Primitivo M, Rintala N, Ramos FJ, Miller DL, Kaeberlein M (2015). Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span. Science. 2015 Nov 19. [Download free text here]
Leiser SF, Fletcher M, Begun A, Kaeberlein M (2013). Life-Span Extension From Hypoxia in Caenorhabditis elegans Requires Both HIF-1 and DAF-16 and Is Antagonized by SKN-1. J. Gerontol. A Biol. Sci. Med. Sci.. 2013 Feb;.
Leiser SF, Begun A, Kaeberlein M (2011). HIF-1 modulates longevity and healthspan in a temperature-dependent manner.. Aging Cell. 2011 Apr; 10(2):318-26.
Leiser SF, Kaeberlein M (2010). The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging. Biol. Chem. 2010 Oct; 391(10):1131-7.
Leiser SF, Kaeberlein M (2010). A role for SIRT1 in the hypoxic response. Mol. Cell. 2010 Jun; 38(6):779-80.
Leiser SF and Miller RA, “Nrf2 signaling, a mechanism for cellular stress resistance in long-lived mice,” Mol Cell Biol. 30(3): 871-84, 2010. PMID# 19933842
Page MM, Salmon AB, Leiser SF, Robb EL, Brown MF, Miller RA, and Stuart JA, “Mechanisms of stress resistance in Snell dwarf mouse fibroblasts: enhanced antioxidant and DNA base excision repair capacity, but no differences in mitochondrial metabolism,” Free Radic Biol Med. 46(8): 1109-18, 2009. PMID# 19439226
Harper JM, Salmon AB, Leiser SF, Galecki AT, and Miller RA, "Skin-derived fibroblasts from long-lived species are resistant to some, but not all, lethal stresses and to the mitochondrial inhibitor rotenone," Aging Cell 6:1-13, 2007. PMID# 17156084
Leiser SF, Salmon AB, and Miller RA, "Correlated resistance to glucose deprivation and cytotoxic agents in fibroblast cell lines from long-lived pituitary dwarf mice," Mech Ageing Dev. 127:821-829, 2006. PMID# 16979221