Updated 03/15/2016

Haeri Choi

Research Interests

Biology of Aging and Cancer

Projects

Dietary Restriction (DR) in C. elegans: Identify genes that interact with DR and modulate its affect on lifespan
Lifespan extension from addition of sorbitol to the growth medium of Caenorhabditis elegans
DDS, 4,4'-diaminodiphenylsulfone, extends lifespan in C.elegans

Degrees

PREVIOUS POSITION HELD

2012-2015 Post-Doctoral Fellow

Pathology Department, University of Washington

(Advisor: Matt Kaeberlein, Ph.D.)

2011-2012 Senior Research Fellow

Institute on Aging, Seoul National University College of Medicine, S. Korea

(Advisor: Sang Chul Park, M.D., Ph.D.)

EDUCATION/TRAINING

2007-2011 Ph.D. in Biochemistry and Molecular Biology

Seoul National University, College of Medicine, S. Korea

Thesis entitled "Modulation of cellular senescence by cell and matrix interaction"

(Advisor: Sang Chul Park, M.D., Ph.D.)

2005-2007 M.S. in Biochemistry and Molecular Biology

Seoul National University, College of Medicine, S. Korea

Thesis entitled "Analysis of gene associated with DNA repair and telomere lengthening in senescent human diploid fibroblast using microarray"

(Advisor: Sang Chul Park, M.D., Ph.D.)

2001-2005 B.S. in Genetic Engineering / B.S. in Gerontology

Hallym University, S. Korea

Thesis entitled “Regulation of Ferric uptake in Escheichia coli: Isolation of a Temperature sensitive mutant”

(Advisor: Ph.D. Se Chan Wee)

Awards

2004 – 2005 National Research Foundation, Ministry of Agriculture and Forestry

2005 Outstanding Undergraduate Research Award, Hallym University

2005-2010 National Research Foundation, Brain Korea 21 Division of Human Life Science

2010 Outstanding Graduate Student Research Award, Seoul National University College of Medicine

Publications

Hae Ri Choi, Hyun Tae Kang, Sung Young Kim, Sung Chun Cho, Ki Baek Lee, Kyung Ok Kim, Kyung A Cho and Sang Chul Park. Integrin av regulates the restoration of senescence in human diploid fibroblasts (Editing)
Kang HT, Lee KB, Choi HR, Kim SY, Park SC. Regain of autophagy and clearance of lipofuscins through its activity during cellular restoration of senescent phenotype (under revision)
Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans Haeri Choi, Devon Chandler-Brown, Shirley Park, Billie R. Ocampo, Shiwen Chen, Anna Le, George L. Sutphin, Lara S. Shamieh, Erica D. Smith, Matt KaeberleinFront Genet. 2015; 6: 316
Searching for the elusive mitochondrial longevity signal in C. elegans. Bennett CF, Choi H, Kaeberlein M. Worm. 2014 Oct 30;3(3):e959404
Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans. Bennett CF, Vander Wende H, Simko M, Klum S, Barfield S, Choi H, Pineda VV, Kaeberlein M. Nat Commun. 2014 Mar 24;5:3483. doi: 10.1038/ncomms4483.
UV-photoconversion of ethosuximide from a longevity-promoting compound to a potent toxin. Choi H, Schneider H, Klum S, Chandler-Brown D, Kaeberlein M, Shamieh L. PLoS One. 2013 Dec 10;8(12):e82543.
Autophagy impairment induces premature senescence in primary human fibroblasts. Kang HT, Lee KB, Kim SY, Choi HR, Park SC. PLoS One. 2011;6(8):e23367
Protective effect of 4,4’-diaminodiphenylsulfone against paraquat-induced mouse lung injury. Cho SC, Rhim JH, Choi HR, Son YH, Lee SJ, Song KY, Park SC. Exp Mol Med. 2011 Sep 30;43(9):525-37.
Defective nuclear translocation of stress-activated signaling in senescent diploid human fibroblasts: a possible explanation for aging-associated apoptosis resistance. Kim SY, Ryu SJ, Kang HT, Choi HR, Park SC. Apoptosis. 2011 Aug;16(8):795-807
Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix. Choi HR, Cho KA, Kang HT, Lee JB, Kaeberlein M, Suh Y, Chung IK, Park SC. Aging Cell. 2011 Feb;10(1):148-57
Biliverdin reductase A in the prevention of cellular senescence against oxidative stress. Kim SY, Kang HT, Choi HR, Park SC. Exp Mol Med. 2011 Jan 31;43(1):15-23.
Reduction of Nup107 attenuates the growth factor signaling in the senescent cells. Kim SY, Kang HT, Choi HR, Park SC. Biochem Biophys Res Commun. 2010 Oct 8;401(1):131-6.
Senescence-related functional nuclear barrier by down-regulation of nucleo-cytoplasmic trafficking gene expression. Kim SY, Ryu SJ, Ahn HJ, Choi HR, Kang HT, Park SC. Biochem Biophys Res Commun. 2010 Jan 1;391(1):28-32.
Age associated high level of major vault protein is p53 dependent. An HJ, Ryu SJ, Kim SY, Choi HR, Chung JH, Park SC. Cell Biochem Funct. 2009 Jul;27(5):289-95.
On the role of major vault protein in the resistance of senescent human diploid fibroblasts to apoptosis. Ryu SJ, An HJ, Oh YS, Choi HR, Ha MK, Park SC. Cell Death Differ. 2008 Nov;15(11):1673-80.

BOOK

Adjustment of Telomere Length by Cell-Matrix Interaction. Choi HR and Park SC. Chapter in: Telomeres: Biological Functions, Sequencing and Aging. Nicolás E. Dominguez et al. eds. NOVA Publishers. 2012

PATENT

Choi Hae Ri, Cho Kyung-A, Ha Moon Kyung, Park Sang Chul: Restoration of cellular senescence by alteration of cell to matrix interaction and Restoration (International patent application number: PCT/KR2009/004212)