Matt Kaeberlein, Ph.D., is recognized globally for his research on the basic biology of aging. The premise of his research is that understanding the molecular mechanisms of aging will lead to interventions that slow the onset and progression of age-related chronic conditions, such as cancer, diabetes, kidney disease, heart disease, Alzheimer’s and others. Dr. Kaeberlein received his Ph.D. from the Massachusetts Institute of Technology in 2002 and performed his post-doctoral research in the Department of Genome Sciences at the University of Washington. Dr. Kaeberlein was appointed as an Assistant Professor of Pathology in 2006 and was promoted to Associate Professor in 2011.

Dr. Kaeberlein has authored more than 140 publications in top scientific journals, including 19 published in Nature and Science, his work has also been featured in the popular press. Dr. Kaeberlein has been recognized with several awards, including a Breakthroughs in Gerontology Award from the Glenn Foundation, an Alzheimer’s Association Young Investigator Award, an Ellison Medical Foundation New Scholar in Aging Award, an Undergraduate Research Mentor of the Year Award, and a Murdock Trust Award. In 2011, he was named the Vincent Cristofalo Rising Star in Aging Research by the American Federation for Aging Research and appointed as a Fellow of the Gerontological Society of America, and in 2012 he joined the Board of Directors of the American Aging Association. Dr. Kaeberlein currently serves on the editorial boards for Science, Aging Cell, Cell Cycle, PloS One, Frontiers in Genetics of Aging, BMC Longevity and Healthspan, F1000 Research, Ageing Research Reviews, and BioEsssays.

In addition to his primary appointment, Dr. Kaeberlein is the Director of the Dog Aging Project, co-Director of the University of Washington Nathan Shock Center of Excellence in the Basic Biology of Aging, the founding Director of the Healthy Aging and Longevity Research Institute, and the current President of the American Aging Association.

Research Interests

  • Biology of aging

Degrees

  • Ph.D. in Biology Massachusetts Institute of Technology 2002
  • B.S. Biochemistry Western Washington University 1997
  • B.A. Mathematics Western Washington University 1997
  • A.A. Highline Community College 1994

Awards

  • 2014 - Nelson Fausto Distinguished Mentor Award
  • 2013 -  M.J. Murdock Charitable Trust Award
  • 2012 - Vincent J. Christofalo Lectureship
  • 2011 - Selected as a Gerontological Society of America Fellow
  • 2011 - American Federation for Aging Research Vincent Cristofalo Rising Star in Aging Research Award
  • 2010 - Co-Director of the University of Washington Nathan Shock Center of Excellence in the Basic Biology of Aging
  • 2009 - Appointed Distinguished Visiting Professor, Institute for Aging Research, Guangdong Medical College, Dongguan, China
  • 2009 - University of Washington Young Investigator Science in Medicine Lecture
  • 2009 - University of Washington Undergraduate Research Mentor Award
  • 2008 - New Scholar in Aging Award, The Ellison Medical Foundation
  • 2008 - Alzheimer’s Association New Investigator Award
  • 2007 - Breakthroughs in Gerontology Award, American Federation for Aging Research and the Glenn Foundation
  • 2006 - American Federation for Aging Research Junior Faculty Research Award
  • 2003 - Postdoctoral Fellowship, Genetic Approaches to Aging Training Grant
  • 1997 - Outstanding Graduate, Western Washington University
  • 1997 - Chang Biochemistry Award, Western Washington University

Publications

  • Defossez, P. A., Prusty, R., Kaeberlein, M., Lin, S. J., Ferrigno, P., Silver, P. A., Keil, R. L., and Guarente, L. (1999). Elimination of replication block protein Fob1 extends the life span of yeast mother cells. Mol Cell 3, 447-55.
  • Kaeberlein, M., McVey, M., and Guarente, L. (1999). The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13, 2570-80.
  • Pultz, M. A., Zimmerman, K. K., Alto, N. M., Kaeberlein, M., Lange, S. K., Pitt, J. N., Reeves, N. L., and Zehrung, D. L. (2000). A genetic screen for zygotic embryonic lethal mutations affecting cuticular morphology in the wasp Nasonia vitripennis. Genetics 154, 1213-29.
  • Imai, S., Armstrong, C. M., Kaeberlein, M., and Guarente, L. (2000). Transcriptional silencing and longevity protein Sir2 is an NAD- dependent histone deacetylase. Nature 403, 795-800.
  • McVey, M., Kaeberlein, M., Tissenbaum, H. A., and Guarente, L. (2001). The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination. Genetics 157, 1531-42.
  • Kaeberlein, M., McVey, M., and Guarente, L. (2001).  Using yeast to discover the fountain of youth.  Sci Aging Knowl Environ 2001, pe1
  • Kaeberlein, M.,  Andalis, A. A., Fink, G. R., and Guarente, L. (2002) High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism resembling calorie restriction.  Mol Cell Biol 22, 8056-66.
  • Kaeberlein, M., Jegalian, B., and McVey, M. (2002). AGEID: a database of aging genes and interventions. Mech Ageing Dev 123, 1115-9.
  • Lin, S. J., Kaeberlein, M., Andalis, A. A., Sturtz, L. A., P., D., Culotta, V. C., Fink, G., and Guarente, L. (2002). Calorie restriction extends Saccharomyces cerevisiae life span by increasing respiration. Nature 418, 344-48.
  • Armstrong, C. M., Kaeberlein, M., Imai, S. I., and Guarente, L. (2002). Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity. Mol Biol Cell 13, 1427-38.
  • Kaeberlein, M., and Guarente, L. (2002). Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics 160, 83-95.
  • Kaeberlein, M. and Russo, S. F.  (2002) A comparison of the thermostability of glyceraldehyde 3-phosphate dehydrogenase from thermophiles and mesophiles in different ionic salt solutions.  Journal of Young Investigators 6.
  • Kaeberlein, M.  Aging research in the ‘omics age’ (2004).  Sci Aging Knowl Environ 2004, pe39
  • Kaeberlein, M., Andalis, A. A., Liszt, G., Fink, G. R., and Guarente, L. (2004) Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism. Genetics 166, 1661-72.
  • Kaeberlein, M., Kirkland, K. T., Fields, S., and Kennedy, B. K. (2004). Sir2-indepdendent life span extension by calorie restriction in yeast. PLoS Biol 2, E296.
  • Hudson, F. N., Kaeberlein, M., Linford, N., Pritchard, D., Beyer, R., and Rabinovitch, P. S. (2005).  Microarray analysis of gene expression changes in aging.  Handbook of the Biology of Aging, 6th Edition.  E.J. Masoro and S. N. Austad (Eds.)
  • Kaeberlein, M., McDonagh, T., Heltweg, B., Hixon, J., Westman, E. A., Caldwell, S. D., Napper, A., Curtis, R., Distefano, P. S., Fields, S., et al. (2005). Substrate-specific activation of sirtuins by resveratrol. J Biol Chem 280, 17038-17045.
  • Kaeberlein, M., Kirkland, K. T., Fields, S., and Kennedy, B. K. (2005). Genes determining yeast replicative life span in a long-lived genetic background. Mech Ageing Dev 126, 491-504.
  • Kaeberlein, M., and Kennedy, B. K. (2005). Large-scale identification in yeast of conserved ageing genes. Mech Ageing Dev 126, 17-21.
  • Kaeberlein, M., Steffen, K. K., Hu D., Dang N., Kerr E.O., Tsuchiya, M., Westman, E. A., Fields, S., Kennedy, B.K. (2005) Calorie restriction increases life span in respiratory deficient yeast. PLoS Genet 1, E69
  • Kaeberlein, M., Powers, R. W., Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., and Kennedy, B. K. (2005). Regulation of yeast replicative life span by Tor and Sch9 in response to nutrients. Science 310, 1193-1196.
  • Kennedy, B. K., Smith, E. D., Kaeberlein, M. (2005) The enigmatic role of sir2 in aging.  Cell 124, 548-550.
  • Kaeberlein, M., (2006).  Longevity and aging in the budding yeast.  Handbook of Models for Human Aging, M. Conn (Ed.)
  • Kaeberlein, M., (2006).  Application of high-throughput technologies to aging-related research.  Handbook of Models for Human Aging, M. Conn (Ed.)
  • Kaeberlein M., Hu, D., Kerr, E. O., Tsuchiya, M., Westman, E. A., Dang, N., Fields, S., Kennedy, B. K. (2006). Author's Reply. PLoS Genet 2, e34.
  • Powers, R. W., Kaeberlein, M., Caldwell, S. D., Kennedy, B. K., Fields, S. (2006). Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev 20, 174-184.
  • Kaeberlein, M., Steffen K.K., Hu D., Dang N., Kerr E.O., Tsuchiya, M., Fields, S., Kennedy, B. K. (2006). Comment on: HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction. Science 312,1312.
  • Kaeberlein, M.  (2006). Genome-wide approaches to understanding human aging. Hum Genom 2, 422-428.
  • Kaeberlein, T, Smith, E. D., Tsuchiya, M., Welton, K. L., Thomas, J. H., Kennedy, B. K., Kaeberlein, M. (2006). Life span extension in Caenorhabditis elegans by complete removal of food.  Aging Cell 5, 487-494.
  • Tsuchiya, M., Dang, N., Kerr, E. O., Hu, D., Steffen, K. K., Oakes, J. A., Kennedy, B. K., Kaeberlein, M. (2006). Sirtuin-independent effects of nicotinamide on life span extension from calorie restriction.  Aging Cell. 5, 505-514.
  • Kaeberlein, M., Rabinovitch, P. S. (2006). Grapes versus gluttony. Nature  444, 280-281.
  • Smith, E. D., Kennedy, B. K., Kaeberlein, M. (2007). Genome-wide identification of conserved longevity genes in yeast and worms. Mech Ageing Dev.  128, 106-111.
  • Lockshon, D., Surface, L.E., Kerr, E. O., Kaeberlein, M., Kennedy, B. K. (2007). The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function. Genetics. 175, 77-91.
  • Kaeberlein, M., Burtner, C. R., Kennedy, B. K. (2007). Recent developments in yeast aging. PLoS Genet.  3, e84.
  • Kennedy, B. K., Steffan, K., Kaeberlein, M. Ruminations on calorie restriction and aging. (2007). Cell Mol Life Sci. 64, 1323-1328.
  • Powers, R. W., Kaeberlein, M. (2007). Sir2 and calorie restriction: A skeptic’s perspective. Age Res. Rev. 6, 128-140.
  • Kaeberlein, M. (2007). Longevity genomics across species.  Curr Genom. 8, 73-78.
  • Kaeberlein, M, Kennedy B. K. (2007). Does resveratrol activate yeast Sir2 in vivo? Aging Cell. 6, 731-734.
  • Kaeberlein, M. (2007). Molecular basis of aging.  EMBO Reports. 8, 907-911.
  • Kaeberlein, M., Kennedy, B. K.  (2007). Protein translation, 2007. Aging Cell 6, 731-734.
  • Schmidlin, T., Kaeberlein, M., Kudlow, B. A., MacKay, V., Lockshon, D., Kennedy, B. K. (2008) Single-gene deletions that restore mating competence to diploid yeast. FEMS Yeast Res. 8, 276-86.
  • Sutphin, G. L. and Kaeberlein, M. (2008). Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes. Exp. Gerontol. 43,130-135.
  • Murakami, C. J., Burtner, C. R., Kennedy, B. K., Kaeberlein, M. (2008).  A method for high-throughput quantitative analysis of yeast chronological life span. J. Gerontol. Biol. Sci. A. 63, 113-121.
  • Smith, E. D., Tsuchiya, M., Fox, L. A., Dang, N., Hu, D., Kerr, E. O., Johnston, E. D., Tchao, B. N., Pak, D. N., Welton, K. L., Promislow, D. E. L., Thomas, J. H., Kaeberlein, M., Kennedy, B. K. (2008). Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome Res. 18, 564-570.
  • Steinkraus, K. A., Smith, E. D., Davis, C., Carr, D., Pendergrass, W. R., Sutphin, G. L., Kennedy, B. K., Kaeberlein, M. (2008). Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in C. elegans.  Aging Cell. 7, 394-404.
  • Steffen, K. K., MacKay, V. L., Kerr, E. O., Tsuchiya, M., Hu, D., Fox, L. A., Dang, N., Johnston, E. D., Oakes, J. A., Tchao, B. N., Pak, D. N., Fields, S., Kennedy, B. K., Kaeberlein, M. (2008).  Yeast lifespan extension by depletion of 60S ribosomal subunits is mediated by Gcn4.  Cell. 133, 292-302.
  • Effros, R. B., Austad, S., Blau, H., Chesselet, M., Ingram, D., Johnson, T. E., Kaeberlein, M., Lundblad, V., McCarter, R., McElhaney, J., Saag, M. (2008). The biological sciences section program at the 60th annual meeting of the Gerontological Society of America.  J. Gerontol. Biol. Sci. A. 63, 331-337.
  • Smith E. D., Kaeberlein, T. L., Lydum, B. T., Sager, J., Welton, K. L., Kennedy, B. K., Kaeberlein, M. (2008). Age- and calorie-independent life span extension from bacterial food deprivation in Caenorhabditis elegans.  BMC Dev. Biol. 8, 59. PMC2408926
  • Steinkraus, K. A., Kaeberlein, M., Kennedy, B. K. (2008). Replicative aging in yeast: the means to the end. Ann. Rev. Cell. Dev. Biol. 24, 29-54.
  • Kaeberlein, M. (2008). The ongoing saga of sirtuins and aging.  Cell Metab. 8, 4-5.
  • Kaeberlein, M., Kennedy, B. K. (2008). Hot topics protein translation, 2008. Aging Cell 7, 777-782.
  • Kaeberlein, M. (2008). A molecular age barrier.  Nature 454, 709-710.
  • Managbanag, J. R., Witten, T. M., Bonchev, D., Fox, T. A., Tsuchiya, M., Kennedy, B. K., Kaeberlein, M. (2008). Shortest-path network analysis Is a useful approach toward identifying genetic determinants of longevity.  PLoS One 3, e3802
  • Burtner, C. R., Murakami, C. J., Kaeberlein, M. (2009). A genomic approach to yeast aging.  Methods Mol Biol 548, 101-114.
  • Burtner, C. R., Murakami, C. J., Kennedy, B., K., Kaeberlein, M. (2009). A molecular mechanism of chronological aging in yeast. Cell Cycle 8, 1256-1270.
  • Murakami, C., Kaeberlein, M. (2009) Quantifying yeast chronological life span by outgrowth of aged cells. J Vis Exp. May 6;(27). pii: 1156. doi: 10.3791/1156.
  • Sutphin, G. L., Kaeberlein, M. (2009) Measuring Caenorhabditis elegans Life Span on Solid Media.  J Vis Exp. May 12;(27). pii: 1152. doi: 10.3791/1152.
  • Steffen, K. K., Kennedy, B. K., Kaeberlein, M. (2009). Measuring Replicative Life Span in the Budding Yeast.  J Vis Exp. Jun 25;(28). pii: 1209. doi: 10.3791/1209.
  • Mehta, R., Steinkraus, K. A., Sutphin, G., Ramos, F. J., Shamieh, L., S., Huh, A., Davis, C., Chandler-Brown, D., Kaeberlein, M. (2009). Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science 324: 1196-1198.
  • Dang, W., Steffen, K. K., Perry, R., Dorsey, J., Johnson, F. B., Shilatifard, A., Kaeberlein, M., Kennedy, B. K., Berger, S. (2009). LHistone H4 lysine-16 acetylation regulates cellular lifespan. Nature 459, 802-807.
  • Stanfel, M. N., Shamieh, L. S., Kaeberlein, M., Kennedy, B. K. (2009). The TOR pathway comes of age.  Biochim Biophys Acta. 1790, 1067-1074.
  • Kaeberlein, M., Kennedy, B. K. (2009) A midlife longevity drug? Nature 460, 331-332.
  • Kaeberlein, M., Kapahi, P. (2009). The hypoxic response and aging.  Cell Cycle 8, 2324.
  • Kennedy, B. K., Kaeberlein, M. (2009). Hot topics in aging research: protein translation. Aging Cell 8, 617-623.
  • Enns, L. C., Morton, J. F., Mangalindan, R. S., McKnight, S., Schwartz, M. W., Kaeberlein, M., Kennedy, B. K., Rabinovitch, P. S., Ladiges, W. (2009) Attenuation of Age-Related Metabolic Dysfunction in Mice With a Targeted Disruption of the C{beta} Subunit of Protein Kinase A..  J. Gerontol. 64, 1221-1231.
  • Kaeberlein, M., Kapahi, P.  (2009). Aging is RSKy Business.  Science 236, 55.
  • Kaeberlein, M. (2009). Spermidine surprise for long life (2009) Nature Cell Biology 11, 1277.
  • Kaeberlein, M. (2010). Sirtuins. McGraw Hill 2010 Yearbook of Science & Technology.
  • Kaeberlein, M., Shamieh, L. S.  (2010). The role of TOR signaling in aging. Comparative Biology of Aging. N. Wolf (Ed.)
  • Mehta, R., Chandler-Brown, D., Ramos, F. J., Shamieh, L. S., Kaeberlein, M. (2010)  Regulation of mRNA translation as a conserved mechanism of longevity control.  Protein Metabolism and Homeostasis in Aging.  N. Tavernarakis (Ed.)
  • Kaeberlein, M. (2010).  Resveratrol and rapamycin: Are they anti-aging drugs?  BioEssays 32, 96.
  • Olson, B. A., Murakami, C. J., Kaeberlein, M. (2010). YODA: Software to facilitate high-throughput analysis of chronological life span, growth rate, and survival in budding yeast. BMC Bioinformatics 11, 141.
  • Kaeberlein, M. (2010). Lessons on longevity from the budding yeast.  Nature 464, 513-519.
  • Leiser, S. L., Kaeberlein, M. (2010).  A role for SIRT1 in the hypoxic response.  Mol Cell. 38, 779-780.
  • Mehta, R., Chandler-Brown, D., Ramos, F. J., Shamieh, L. S., Kaeberlein, M. (2010).  Regulation of mRNA translation as a conserved mechanism of longevity control. Adv Exp Med Biol. 694,14-29.
  • Leiser, S. L., Kaeberlein, M. (2010). The hypoxia inducible factor HIF-1 functions as both a positive and negative modulator of aging.  Biol Chem. 391, 1131
  • Choi, H. R., Cho, K. A., Kang, H. T., Lee, J. B. Kaeberlein, M., Suh, Y., Chung, K., Park, S. C. (2011). Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix.  Aging Cell. 10, 148-57.
  • Sutphin, G. L., Olsen, B. A., Kennedy, B. K., Kaeberlein, M. (2011). Genome-wide analysis of aging in yeast.  Aging Research in Yeast.  M. Breitenbach, S. M. Jazwinski, P. Laun (Eds.) 
  • Kaeberlein, M. and Kennedy, B. K. (2011).  Hot topics in aging research: Protein translation and TOR signaling, 2010.  Aging Cell. 10, 185-190
  • Sutphin, G. L., Kaeberlein, M.  (2011).  Comparative genetics of aging. Handbook of the Biology of Aging, 7th Edition.  E.J. Masoro and S. N. Austad (Eds.)
  • Kaeberlein, M., Kennedy, B. K., Liu, X., Suh, Y., Zhou, Z. (2011)  Trinations aging symposium.  Mech Age Dev. 132, 348-352.
  • Delaney, J. R., Murakami, C. J., Olsen, B., Kennedy, B. K., Kaeberlein, M. (2011). Quantitative evidence for fitness defects from 32 longevity-associated alleles in yeast.  Cell Cycle 10, 156-165.
  • Burtner,C. R., Murakami, C. J., Olsen, B., Kennedy, B. K., Kaeberlein, M. (2011). A genomic analysis of chronological longevity factors in yeast. Cell Cycle 10, 1385-1396.
  • Leiser, S. F., Begun, A., Kaeberlein, M. (2011). HIF-1 modulates longevity and healthspan in a temperature-dependent manner.  Aging Cell 10, 318-326.
  • Murakami, C. J., Wall, V., Basisty, N., Kaeberlein, M. (2011). Composition and acidification of the culture medium influences chronological aging similarly in vineyard and laboratory yeast. PLoS One 6, e24530.
  • Burnett, C., Valentini, S., Cabreiro, F., Goss, M., Somogyvári. M., Piper, M. D., Hoddinott, M., Sutphin, G. L., Leko, V., McElwee, J. J., Vazquez-Manrique, R. P., Orfila, A. M., Ackerman, D., Au, C., Vinti, G., Riesen, M., Howard, K., Neri, C., Bedalov, A., Kaeberlein, M., Soti, C., Partridge, L., Gems, D. (2011). Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature 477, 482-485.
  • Kruegel, U., Robison, B., Dange, T., Kahlert, G., Delaney, J. R., Kotireddy, S., Tsuchiya, M., Tsuchiyama, S., Murakami, C. J., Schleit, J., Sutphin, G., Carr, D., Tar, K., Dittmar, G., Kaeberlein, M., Kennedy, B. K., Schmidt, M. (2011). Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae. PLoS Genet 7, e1002253.
  • Delaney, J. R., Sutphin, G. L., Dulken, B., Sim, S., Kim, J. R., Robison, B., Schleit, J., Murakami, C. J., Carr, D., An, E. H., Choi, E., Chou, A., Fletcher, M., Jelic, M., Liu, B., Lockshon, D., Moller, R. M., Pak, D. N., Peng, Q., Peng, Z. J., Pham, K. M., Sage, M., Solanky, A., Steffen, K. K., Tsuchiya, M., Tsuchiyama, S., Johnson, S., Raabe, C., Suh, Y., Zhou, Z., Liu, X., Kennedy, B. K., Kaeberlein, M. (2011). Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Aging Cell 10, 1089-1091.
  • Schleit J, Wall VZ, Simko M, Kaeberlein M. (2011). The MDT-15 Subunit of Mediator Interacts with Dietary Restriction to Modulate Longevity and Fluoranthene Toxicity in Caenorhabditis elegans. PLoS One 6, e28036. PMC3221695
  • Sutphin, GL, Olsen, BA, Kennedy, BK, Kaeberlein, M. (2012). Genome-wide analysis of yeast aging. Subcell Biochem 57, 251-289.
  • Kaeberlein M, Kennedy BK. (2012).  A new chronological aging assay. Cell Cycle 11, 201-202.
  • Steffen KK, McCormick MA, Pham KM, MacKay VL, Delaney JR, Murakami CJ, Kaeberlein M, Kennedy BK. (2012) Ribosome deficiency protects against ER stress in Saccharomyces cerevisiae. Genetics 191, 107-118.
  • Zhou B, Yang L, Li S, Huang J, Chen H, Hou L, Wang J, Green CD, Yan Z, Huang X, Kaeberlein M, Zhu L, Xiao H, Liu Y, Han JD. (2012). Midlife gene expressions identify modulators of aging through dietary interventions. Proc Natl Acad Sci U S A. 109, E1209-1209.
  • Kaeberlein M. (2012).  Hypertrophy and senescence factors in yeast aging. FEMS Yeast Res 12, 269-270.
  • Ramos FJ, Kaeberlein M. (2012). Ageing: A healthy diet for stem cells.  Nature 486, 477-478.
  • Ramos FJ, Chen SC, Garelick MG, Dai DF, Liao CY, Schreiber KH, MacKay VL, An EH, Strong R, Ladiges WC, Rabinovitch PS, Kaeberlein M, Kennedy BK. (2012). Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival, Sci Transl Med. 4, 144ra103.
  • Longo VD, Shadel GS, Kaeberlein M, Kennedy B. (2012). Replicative and Chronological Aging in Saccharomyces cerevisiae, Cell Metab. 16, 18-31.
  • Schleit J, Wasko BM, Kaeberlein M. (2012). Yeast as a model to understand the interaction between genotype and the response to calorie restriction, FEBS Lett. 586, 2868-2873.
  • Murakami C, Delaney JR, Chou A, Carr D, Schleit J, Sutphin GL, An EH, Castanza AS, Fletcher M, Goswami S, Higgins S, Holmberg M, Hui J, Jelic M, Jeong KS, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Moller R, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Schuster A, Singh M, Spector BL, Vander Wende H, Wang AM, Wasko BM, Olsen B, Kaeberlein M. (2012). pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast. Cell Cycle 11, 3087-3096.
  • Delaney JR, Murakami C, Chou A, Carr D, Schleit J, Sutphin GL, An EH, Castanza AS, Fletcher M, Goswami S, Higgins S, Holmberg M, Hui J, Jelic M, Jeong KS, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Moller R, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Schuster A, Singh M, Spector BL, Wende HV, Wang AM, Wasko BM, Olsen B, Kaeberlein M. (2012). Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae. Exp Gerontol. 48, 1006-1013.
  • Liu B, Ghosh S, Yang X, Zheng H, Liu X, Wang Z, Jin G, Zheng B, Kennedy BK, Suh Y, Kaeberlein M, Tryggvason K, Zhou Z. (2012). Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria.  Cell Metab 16, 738-750.
  • Yanos ME, Bennett CF, Kaeberlein M. (2012). Genome-Wide RNAi Longevity Screens in Caenorhabditis elegans. Curr Genomics 13, 508-518.
  • Kaeberlein M. (2012). Genomics and genetics of aging. Curr Genomics 13, 499.
  • Delaney JR, Ahmed U, Chou A, Sim S, Carr D, Murakami CJ, Schleit J, Sutphin GL, An EH, Castanza A, Fletcher M, Higgins S, Jelic M, Klum S, Muller B, Peng ZJ, Rai D, Ros V, Singh M, Wende HV, Kennedy BK, Kaeberlein M. (2013). Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. Aging Cell 12, 156-166.
  • Ramos, F.J., Kaeberlein, M.,  Kennedy, B.K. (2013). Elevated MTORC1 signaling and impaired autophagy. Autophagy 9, 108-109.
  • Delaney JR, Chou A, Olsen B, Carr D, Murakami C, Ahmed U, Sim S, An EH, Castanza AS, Fletcher M, Higgins S, Holmberg M, Hui J, Jelic M, Jeong KS, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Moller R, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Schleit J, Schuster A, Singh M, Spector BL, Sutphin GL, Wang AM, Wasko BM, Vander Wende H, Kennedy BK, Kaeberlein M. (2013). End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging. FEMS Yeast Res 13, 267-276.
  • Johnson SC, Rabinovitch PS, Kaeberlein M. (2013). mTOR is a key modulator of ageing and age-related disease.  Nature 493, 338-45.
  • Kaeberlein, M. (2013). Longevity and aging. F1000 Prime Rep. 5, 5.
  • Kwan EX, Foss EJ, Tsuchiyama S, Alvino GM, Kruglyak L, Kaeberlein M, Raghuraman MK, Brewer BJ, Kennedy BK, and Bedalov A. (2013). A Natural Polymorphism in rDNA Replication Origins Links Origin Activation with Calorie Restriction and Lifespan. PLoS Genet 9, e1003329.
  • Sutphin GL, Bishop E, Yanos ME, Moller RM, Kaeberlein M. (2012). Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegans. Longevity & Healthspan 1, 9.
  • Leiser SF, Fletcher M, Begun A, Kaeberlein M. (2013). Life-Span Extension From Hypoxia in Caenorhabditis elegans Requires Both HIF-1 and DAF-16 and Is Antagonized by SKN-1. J Gerontol A Biol Sci Med Sci. 68, 1135-1144.
  • Xian B, Shen J, Chen W, Sun N, Qiao N, Jiang D, Yu T, Men Y, Han Z, Pang Y, Kaeberlein M, Huang Y, Han JD. (2013). WormFarm: a quantitative control and measurement device toward automated Caenorhabditis elegans aging analysis. Aging Cell. 12, 398-409.
  • Schleit J, Johnson SC, Bennett CF, Simko M, Trongtham N, Castanza A, Hsieh EJ, Moller RM, Wasko BM, Delaney JR, Sutphin GL, Carr D, Murakami CJ, Tocchi A, Xian B, Chen W, Yu T, Goswami S, Higgins S, Jeong KS, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Olsen B, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Singh M, Spector BL, Wende HV, An EH, Fletcher M, Jelic M, Rabinovitch PS, Maccoss MJ, Han JD, Kennedy BK, Kaeberlein M. (2013). Molecular mechanisms underlying genotype-dependent responses to dietary restriction. Aging Cell 12, 1050-1061. 3838465
  • O'Leary MN, Schreiber KH, Zhang Y, Duc AC, Rao S, Hale JS, Academia EC, Shah SR, Morton JF, Holstein CA, Martin DB, Kaeberlein M, Ladiges WC, Fink PJ, Mackay VL, Wiest DL, Kennedy BK. (2013). The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1. PLoS Genet 9, e1003708. 3750023
  • Wasko BM, Kaeberlein M. (2013). Yeast replicative aging: A paradigm for defining conserved longevity interventions. FEMS Yeast Res.
  • Kaeberlein M. (2013). Deciphering the role of natural variation in age-related protein homeostasis. BMC Biol 11, 102.
  • Kaeberlein M. (2013). mTOR Inhibition: From Aging to Autism and Beyond. Scientifica 2013, 849186. 3860151
  • Choi H, Schneider H, Klum S, Chandler-Brown D, Kaeberlein M, Shamieh L. (2013). UV-Photoconversion of Ethosuximide from a Longevity-Promoting Compound to a Potent Toxin. PLoS One 8, e82543. 3858337
  • Johnson SC, Yanos ME, Kayser EB, Quintana A, Sangesland M, Castanza A, Uhde L, Hui J, Wall VZ, Gagnidze A, Oh K, Wasko BM, Ramos FJ, Palmiter RD, Rabinovitch PS, Morgan PG, Sedensky MM, Kaeberlein M. (2013). mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome. Science 342, 1524-1528.
  • Johnson SC, Martin GM, Rabinovitch PS, Kaeberlein M. (2013). Preserving youth: does rapamycin deliver? Sci Transl Med 5, 211fs240.
  • Labunskyy VM, Gerashchenko MV, Delaney JR, Kaya A, Kennedy BK, Kaeberlein M, Gladyshev VN. (2014). Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response. PLoS Genet 10, e1004019.  PMC: 3879150
  • Promislow DE, Kaeberlein M. (2014). Development. Chemical warfare in the battle of the sexes. Science 343, 491-492.
  • Sutphin GL, Delaney JR, Kaeberlein M. (2014).  Replicative life span analysis in budding yeast. Methods Mol Biol. 1205, 341-57.
  • Pitt JN, Leiser SF, Kaeberlein M. (2014) Oxygen and aging.  Annual Review of Gerontology and Geriatrics 34,  59-91.
  • Bennett CF, Vander Wende H, Simko M, Klum S, Barfield S, Choi H, Pineda VV, Kaeberlein M. (2014). Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans. Nature communications 5, 3483.
  • Zhao W, Fang BX, Niu YJ, Liu YN, Liu B, Peng Q, Li JB, Wasko BM, Delaney JR, Kennedy BK, Suh Y, Zhou ZJ, Kaeberlein M, Liu XG. (2014). Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase. Mech Ageing Dev 138, 53-58.
  • Kaeberlein M. (2014). Rapamycin and ageing: when, for how long, and how much? Journal of genetics and genomics  41, 459-463.  PMC: 4401992
  • Wasko BM, Carr DT, Tung H, Doan H, Schurman N, Neault JR, Feng J, Lee J, Zipkin B, Mouser J, Oudanonh E, Nguyen T, Stetina T, Shemorry A, Lemma M, Kaeberlein M. (2013). Buffering the pH of the culture medium does not extend yeast replicative lifespan. F1000Research 2, 216.  PMC: 3886788
  • Bennett CF, Kaeberlein M. (2014). The mitochondrial unfolded protein response and increased longevity: cause, consequence, or correlation? Exp Gerontol 56, 142-146.  PMC: 4048780
  • Dang W, Sutphin GL, Dorsey JA, Otte GL, Cao K, Perry RM, Wanat JJ, Saviolaki D, Murakami CJ, Tsuchiyama S, Robison B, Gregory BD, Vermeulen M, Shiekhattar R, Johnson FB, Kennedy BK, Kaeberlein M, Berger SL. (2014). Inactivation of Yeast Isw2 Chromatin Remodeling Enzyme Mimics Longevity Effect of Calorie Restriction via Induction of Genotoxic Stress Response. Cell Metab 19, 952-966.
  • Bitto A, Kaeberlein M. (2014). Rejuvenation: It’s in our blood.  Cell Metab 20, 2-4.
  • McCormick MA, Mason AG, Guyenet SJ, Dang W, Garza RM, Ting MK, Moller RM, Berger SL, Kaeberlein M, Pillus L, La Spada AR, Kennedy BK. (2014). The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction. Cell Rep 8, 477-86.
  • Burman JL, Itsara LS, Kayser EB, Suthammarak W, Wang AM, Kaeberlein M, Sedensky MM, Morgan PG, Pallanck LJ. (2014). A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer. Dis Model Mech. 7:1165-74. PMC: 4174527
  • He C, Tsuchiyama SK, Nguyen QT, Plyusnina EN, Terrill SR, Sahibzada S, Patel B, Faulkner AR, Shaposhnikov MV, Tian R, Tsuchiya M, Kaeberlein M, Moskalev AA, Kennedy BK, Polymenis M. (2014). Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import. PLoS Genet 10, e1004860.  PMC: 4270464
  • Cui HJ, Liu XG, McCormick M, Wasko BM, Zhao W, He X, Yuan Y, Fang BX, Sun XR, Kennedy BK, Suh Y, Zhou ZJ, Kaeberlein M, Feng WL. (2015). PMT1 deficiency enhances basal UPR activity and extends replicative lifespan of Saccharomyces cerevisiae. AGE 37(3):9788.
  • Johnson SC, Sangesland M, Kaeberlein M, Rabinovitch PS. (2015). Modulating mTOR in aging and in health. Interdiscip Top Gerontol. 40:107-27.
  • Wang AM, Promislow DE, Kaeberlein M. (2015). Fertile waters for aging research. Cell 160, 814-815.
  • Cho S, Cho M, Kim J, Kaeberlein M, Lee SJ, Suh Y. (2015). Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1alpha in a FOXO3-dependent mechanism. Oncotarget 6, 43-55.  PMC: 4381577
  • Xiong XD, Jung HJ, Gombar S, Park JY, Zhang CL, Zheng H, Ruan J, Li JB, Kaeberlein M, Kennedy BK, Zhou Z, Liu X, Suh Y. (2015). MicroRNA transcriptome analysis identifies miR-365 as a novel negative regulator of cell proliferation in Zmpste24-deficient mouse embryonic fibroblasts. Mutat Res. 777:69-78.
  • Pitt JN, Kaeberlein M. (2015).  Why is aging conserved and what can we do about it? PLoS Biol 13(4):e1002131.
  • Kaeberlein M. (2015). The Biology of Aging: Citizen Scientists and Their Pets as a Bridge Between Research on Model Organisms and Human Subjects. Vet Pathol. Jun 15.
  • Sen P, Dang W, Donahue G, Dai J, Dorsey J, Cao X, Liu W, Cao K, Perry R, Lee JY, Wasko BM, Carr DT, He C, Robison B, Wagner J, Gregory BD, Kaeberlein M, Kennedy BK, Boeke JD, Berger SL. (2015). H3K36 methylation promotes longevity by enhancing transcriptional fidelity. Genes Dev. 2015 Jul 1;29(13):1362-76.
  • Johnson SC, Yanos ME, Bitto A, Castanza A, Gagnidze A, Gonzalez B, Gupta K, Hui J, Jarvie C, Johnson BM, Letexier N, McCanta L, Sangesland M, Tamis O, Uhde L, Van Den Ende A, Rabinovitch PS, Suh Y, Kaeberlein M. (2015). Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mcie.  Front. Genet. 6:247. doi: 10.3389/fgene.2015.00247. eCollection 2015
  • Vermulst M, Denney AS, Lang MJ, Hung CW, Moore S, Mosely AM, Thompson WJ, Madden V, Gauer J, Wolfe KJ, Summers DW, Schleit J, Sutphin GL, Haroon S, Holczbauer A, Caine J, Jorgenson J, Cyr D, Kaeberlein M, Strathern JN, Duncan MC, Erie DA. (2015). Transcription errors induce proteotoxic stress and shorten cellular lifespan. Nat Commun. Aug 25;6:8065. doi: 10.1038/ncomms9065.
  • Yang J, McCormick MA, Zheng J, Xie Z, Tsuchiya M, Tsuchiyama S, El-Samad H, Ouyang Q, Kaeberlein M, Kennedy BK, Li H. (2015). Systematic analysis of asymmetric partitioning of yeast proteome between mother and daughter cells reveals "aging factors" and mechanism of lifespan asymmetry. Proc Natl Acad Sci U S A. 2015 Sep 8. pii: 201506054.