Molecular Mechanisms of Calorie Restriction

By: Fresnida Ramos

Calorie restriction (significant reduction in caloric intake without malnutrition) is an intervention that has been shown to increase lifespan and healthspan in multiple organisms and several studies have shown that the TOR pathway is involved in the molecular mechanism of calorie restriction-mediated lifespan extension. 

However, not that much is known about the effects of re-instating ad libitum (AL) feeding after prolonged calorie restriction (CR).  Preliminary data suggests that re-instating ad libitum (AL) feeding after prolonged calorie restriction (CR) may have negative effects that counteract the benefits previously gained from CR.  Our goal is to determine the effects of switching from long-term CR back to AL on lifespan, healthspan, and the molecular pathways involved in aging.