By Fresnida Ramos

Overall goal of my project is to determine the role of the hypoxic response pathway in TOR-mediated
longevity. Specifically, I aim to determine the role of hif-1 in the mechanistic basis of lifespan extension
by inhibition of TOR and to determine the role of hif-1 in the cellular functions of the TOR pathway. My
approach is to test the effect of hif-1 deficiency/stabilization on lifespan extension and gene expression
mediated by pharmacological and genetic inhibition of the TOR pathway. In addition, I will also test
the effect of hif-1 deficiency/stabilization on the cellular functions of the TOR pathway such as protein
synthesis and autophagy.