By: Richard Moller
My new independent project focuses on translational effects seen in C. elegans under conditions of dietary restriction (DR), also known as caloric restriction. DR has been shown - by our lab and others - to increase C. elegans lifespan. My project will test the hypothesis that this increase is the result of a decrease in global translation. Upstream effectors of translation rates such as the Target of Rapamycin (TOR) signaling pathway and the insulin signaling pathway show links to lifespan extension by DR. Genetic manipulations to elucidate the role of translation in dietary restriction are of interest.