Updated 05/03/2016

Jason Pitt

Research Interests

Our lab has discovered that activation of genetic programs normally required to survive exposure to low oxygen (hypoxia) in normal oxygen concentrations (normoxia) results in a large increases in the lifespan of the nematode C. elegans.  My work focuses on the pathways activated by low oxygen and how they control aging in the worm.





Rapid construction of empirical RNA fitness landscapes.
Pitt JN, Ferré-D'Amaré AR.
Science. 2010 Oct 15;330(6002):376-9. doi: 10.1126/science.1192001.
PMID: 20947767

SEWAL: an open-source platform for next-generation sequence analysis
and visualization.
Pitt JN, Rajapakse I, Ferré-D'Amaré AR.
Nucleic Acids Res. 2010 Dec;38(22):7908-15. doi: 10.1093/nar/gkq661.
Epub 2010 Aug 6.
PMID: 20693400

Perinuclear P granules are the principal sites of mRNA export in adult
C. elegans germ cells.
Sheth U, Pitt J, Dennis S, Priess JR.
Development. 2010 Apr;137(8):1305-14. doi: 10.1242/dev.044255. Epub 2010 Mar 10.
PMID: 20223759

Structure-guided engineering of the regioselectivity of RNA ligase ribozymes.
Pitt JN, Ferré-D'Amaré AR.
J Am Chem Soc. 2009 Mar 18;131(10):3532-40. doi: 10.1021/ja8067325.
PMID: 19220054

A major role for zygotic hunchback in patterning the Nasonia embryo.
Pultz MA, Westendorf L, Gale SD, Hawkins K, Lynch J, Pitt JN, Reeves
NL, Yao JC, Small S, Desplan C, Leaf DS.
Development. 2005 Aug;132(16):3705-15.
PMID: 16077090

How RNA closes a Diel.
Pitt JN, Ferré-D'Amaré AR.
Nat Struct Mol Biol. 2005 Mar;12(3):206-8. No abstract available.
PMID: 15744318

Analysis of RNA associated with P granules in germ cells of C. elegans adults.
Schisa JA, Pitt JN, Priess JR.
Development. 2001 Apr;128(8):1287-98.
PMID: 11262230

A genetic screen for zygotic embryonic lethal mutations affecting
cuticular morphology in the wasp Nasonia vitripennis.
Pultz MA, Zimmerman KK, Alto NM, Kaeberlein M, Lange SK, Pitt JN,
Reeves NL, Zehrung DL.
Genetics. 2000 Mar;154(3):1213-29.
PMID: 10866651

P granules in the germ cells of Caenorhabditis elegans adults are
associated with clusters of nuclear pores and contain RNA.
Pitt JN, Schisa JA, Priess JR.
Dev Biol. 2000 Mar 15;219(2):315-33.
PMID: 10694425

Extensive zygotic control of the anteroposterior axis in the wasp
Nasonia vitripennis.
Pultz MA, Pitt JN, Alto NM.
Development. 1999 Feb;126(4):701-10.
PMID: 9895318