Post-doc
amwang@uw.edu
Updated 02/05/2013

Adrienne Wang

Research Interests

Degrees

Publications

Murakami C, Delaney JR, Chou A, Carr D, Schleit J, Sutphin GL, An EH, Castanza AS, Fletcher M, Goswami S, Higgins S, Holmberg M, Hui J, Jelic M, Jeong KS, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Moller R, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Schuster A, Singh M, Spector BL, Vander Wende H, Wang AM, Wasko BM, Olsen B, Kaeberlein M (2012). pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast.. Cell Cycle. 2012 Aug; 11(16).

Bergman C.M., Pfeiffer B.D., Rincoln-Limas D.E., Hoskins R.A.,Gnirke A., Mungall C.J., Wang A.M., Kronmiller B., Pacleb J., Park S., Stapleton M., Wan K., George R.A., Jong P.J., Botas J., Rubin G.M., Celniker S.E. (2002) Assessing the Impact of Comparative Genomic Sequence Data on the Functional Annotation of the Drosophila Genome. Genome Biol. 2002;3(12). PMCID: PM12537575

Morishima Y, Wang AM, Yu Z, Pratt WB, Osawa Y, Lieberman AP.  CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins. Hum Mol Genet, 17:3942-3952, 2008. PMCID: PMC2605787

Yu Z, Wang A, Robbins DM, Lieberman AP.  Altered RNA splicing contributes to skeletal muscle pathology in Kennedy disease knock-in mice.  Dis Model Mech, 2:500-507, 2009.  (Highlighted in “In This Issue”.)  PMCID: PMC2737058

*Wang AM, Morishima Y, Clapp KM, Peng HM, Pratt WB, Gestwicki JE, Lieberman AP.  Inhibition of Hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation.  J Biol Chem, 285:15714-15723, 2010. PMCID: PMC2871437.

Yu Z, *Wang AM, Adachi H, Katsuno M, Sobue G, Yue Z, Robins DM, Lieberman AP. Macroautophagy is regulated by the UPR-mediator CHOP and accentuates the phenotype of SBMA mice. PLoS Genet 2011;7(10).

Wang AM, Miyata Y, Klinedinst S, Peng HM, Chua JC, Komiyama T, Merry DE, Pratt WB, Osawa Y, Collins CA, Gestwicki JE, Lieberman AP. Allosteric activation of Hsp70 binding promotes polyglutamine androgen receptor clearance and rescues toxicity in a Drosophila model of spinobulbar muscular atrophy. Nat Chem Biol. 2013 Feb;9(2):112-8

* denotes co-first authorship